Insomnia and the Orexinergic Pathway in the Link with Psychopathology: Effects of DORAs in Insomnia Comorbid with Mental Disturbances

期刊论文
发表日期：

2024年4月18日

查看全文

Laura Palagini,
Pierre Alexis Geoffroy,
Gaspare Alfi,
Eric Annuzzi,
Riccardo Gurrieri,
Valerio Caruso,
Mario Miniati,
Angelo Gemignani,
Dieter Riemann

摘要

Purpose of Review

Insomnia can act as a precipitating factor, a comorbid disorder, or a transdiagnostic element for many mental disorders. The stress system’s hyperactivation has been identified as the key factor in insomnia that contributes to mental disorders. It is possible that insomnia may utilize the orexinergic pathway as a link with psychopathology. Thus, this review is aimed at discussing how the orexinergic pathway may play a role in insomnia and psychopathology. We reviewed all available data regarding the effect of DORAs on insomnia and comorbid mental disturbances in a systematic manner.

Recent Findings

PRISMA guidelines have led to the selection of 19 studies on the use of DORAs in preclinical, experimental, and clinical studies including, sleep, insomnia, and mental conditions.

Summary

Although further investigation is needed, targeting insomnia by using DORAs can be considered a promising therapeutic approach for psychiatric disorders.