Background <p>International medical students are exposed to complex cultural and academic environments that require continuous adaptation to both their host society and their culture of origin. This study examines acculturation among international medical students in Hungary using Berry’s Acculturation Theory, which classifies individuals into four categories: Integration, Separation, Assimilation, and Marginalization.</p> Methods <p>A cross-sectional study was conducted among 326 international medical students using a modified Stephenson Multigroup Acculturation Scale and self-reported measures of health behaviours, perceived stress, and mental well-being. Most participants were categorized as either Integration (46.0%) or Separation (50.9%), while only a small portion of students fell into Assimilation (0.3%) or Marginalization (2.8%) category. Consequently, the analysis focused on comparing the Integration and Separation groups.</p> Results <p>Significant differences were observed in demographic and behavioural characteristics between these groups. Males (adjusted odds ratio [aOR] = 1.88, <i>p</i> = 0.013), preclinical students (aOR = 1.78, <i>p</i> = 0.048), non-drinking students (aOR = 2.57, <i>p</i> = 0.001), and those with lower perceived stress (aOR = 2.15, <i>p</i> = 0.035), integrated stronger. Meanwhile, non-smokers (aOR = 0.52, <i>p</i> = 0.040) and those who abstain from psychologist visits (aOR = 0.36, <i>p</i> = 0.008) integrated less well.</p> Conclusion <p>The present study identifies demographic and health-related factors associated with integration among international medical students. These findings may contribute to a better understanding of acculturation patterns and inform strategies to support students’ social adjustment and well-being.</p>