<p>The evolution of health professions education has increased reliance on learning and development specialists for creating new instructional and curricular resources. To facilitate collaboration between health professions educators (HPE) and these instructional specialists, we present a transdisciplinary model called Agile eVidence-Informed Design (<i>AVID</i>esign). Traditional systematic design processes can be cumbersome for HP educators, resulting in a need for more adaptable approaches. <i>AVID</i>esign builds on established systematic and agile design principles to improve practical application in health professions education. <i>AVID</i>esign steps correlate with the familiar steps used in the practice of evidence-based medicine (EBM) used for patient care. Three detailed design cases illustrate step-by-step applications of this model in health professions education, demonstrating how it supports real-world curriculum development in diverse instructional settings.</p>