<p>Under the background of globalization and deep integration of digital technology, nature museums, as an important carrier of cross-cultural communication, are facing the challenge of how to balance scientific universality and cultural uniqueness. The rise of Artificial Intelligence Generated Content (AIGC) technology provides an innovative path for the design of nature museum exhibition space and cross-cultural communication. This paper focuses on the application of AIGC in the outline generation, space design and content adaptation of nature museums, and analyzes how it breaks through the traditional bottleneck in cross-cultural communication, realizes the construction of cultural semantics and emotional resonance through technological empowerment, and provides theoretical and practical references to enhance the effectiveness of the international communication of nature museums.</p>