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<p>Anaphylaxis is a&#xa0;potentially life-threatening type&#xa0;1 hypersensitivity reaction mediated by specific IgE. Culprit allergens frequently include foods, drugs, and insect venom. Sulfites are widely used as additives in food processing but also occur naturally in high concentrations in certain foods. Additionally, they are added as preservatives to aqueous cosmetic and medical solutions. Sulfites have been reported to cause a&#xa0;variety of allergic reactions including anaphylaxis. Here, we present a&#xa0;case of a&#xa0;patient with repetitive anaphylactic reactions to sulfites in food. An allergy workup showed a&#xa0;positive prick test to sodium metabisulfite and a&#xa0;positive oral provocation test. Our patient was successfully treated for anaphylaxis with a&#xa0;sulfite-containing adrenaline auto-injector, suggesting the benefits of adrenaline outweigh the theoretical risks in an acute anaphylactic setting.</p>

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Successful treatment of anaphylaxis to sulfites with sulfite-containing adrenaline auto-injector

  • 期刊论文

  • 发表日期：

    2025年4月17日

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  • Jolien Isabel Kessels,
  • Jan Gutermuth,
  • Martine Grosber

摘要

Anaphylaxis is a potentially life-threatening type 1 hypersensitivity reaction mediated by specific IgE. Culprit allergens frequently include foods, drugs, and insect venom. Sulfites are widely used as additives in food processing but also occur naturally in high concentrations in certain foods. Additionally, they are added as preservatives to aqueous cosmetic and medical solutions. Sulfites have been reported to cause a variety of allergic reactions including anaphylaxis. Here, we present a case of a patient with repetitive anaphylactic reactions to sulfites in food. An allergy workup showed a positive prick test to sodium metabisulfite and a positive oral provocation test. Our patient was successfully treated for anaphylaxis with a sulfite-containing adrenaline auto-injector, suggesting the benefits of adrenaline outweigh the theoretical risks in an acute anaphylactic setting.