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<p>Prolactin contributes to metabolic adaptation during pregnancy by modulating beta-cell function and glucose homeostasis. Clinical evidence suggests a non-linear and time-dependent relationship with gestational diabetes mellitus, in which both reduced levels in late gestation and alterations in hormonal dynamics may be associated with metabolic dysfunction. Large-scale prospective studies are needed to define its value as an early biomarker of impaired glucose metabolism.</p>

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Il ruolo metabolico della prolattina in gravidanza: nuove prospettive cliniche

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

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  • Roberta Scairati,
  • Guendalina Del Vecchio,
  • Chiara Graziadio,
  • Nunzia Verde,
  • Federico Scandone,
  • Francesco Castaldo,
  • Rosario Pivonello,
  • Renata S. Auriemma,
  • Annamaria Colao

摘要

Prolactin contributes to metabolic adaptation during pregnancy by modulating beta-cell function and glucose homeostasis. Clinical evidence suggests a non-linear and time-dependent relationship with gestational diabetes mellitus, in which both reduced levels in late gestation and alterations in hormonal dynamics may be associated with metabolic dysfunction. Large-scale prospective studies are needed to define its value as an early biomarker of impaired glucose metabolism.