Scholarlink

<p>Diabetes mellitus poses an escalating challenge among non-communicable diseases, with substantial socioeconomic burden driven by diabetes-related complications (DRCs). This comprehensive review explores the legacy effect and glycaemic variability (GV) impact on chronic diabetic complications. Evidence shows that intensive glycaemic control significantly reduces microvascular complications, with sustained benefits persisting beyond the intervention period (legacy effect). Multiple GV parameters have emerged as independent predictors of diabetic complications, including long-term measures (HbA1c variability) and short-term metrics (MAGE, TIR, MODD). Studies consistently show that higher GV correlates with increased risk of retinopathy, nephropathy, and cardiovascular events, independent of mean glucose levels. The clinical implications suggest that comprehensive diabetes management should incorporate both pursuing strict glycaemic targets in early stages of diabetes and glycaemic variability reduction strategies to optimise long-term outcomes and minimise DRC burden.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Oltre i target glicemici: effetto legacy e variabilità glicemica nelle complicanze del diabete

  • 期刊论文

  • 发表日期：

    2026年3月9日

查看全文
  • Sara Barone,
  • Luca Sacchetta

摘要

Diabetes mellitus poses an escalating challenge among non-communicable diseases, with substantial socioeconomic burden driven by diabetes-related complications (DRCs). This comprehensive review explores the legacy effect and glycaemic variability (GV) impact on chronic diabetic complications. Evidence shows that intensive glycaemic control significantly reduces microvascular complications, with sustained benefits persisting beyond the intervention period (legacy effect). Multiple GV parameters have emerged as independent predictors of diabetic complications, including long-term measures (HbA1c variability) and short-term metrics (MAGE, TIR, MODD). Studies consistently show that higher GV correlates with increased risk of retinopathy, nephropathy, and cardiovascular events, independent of mean glucose levels. The clinical implications suggest that comprehensive diabetes management should incorporate both pursuing strict glycaemic targets in early stages of diabetes and glycaemic variability reduction strategies to optimise long-term outcomes and minimise DRC burden.