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<p>Osteosarcopenia is a recently recognised geriatric syndrome characterised by the concurrent manifestation of osteoporosis and sarcopenia – two interrelated conditions that synergistically exacerbate frailty, disability, and mortality in the ageing population. The aetiology of osteosarcopenia is multifactorial, involving intricate interplays among genetic susceptibility, endocrine dysregulation, chronic low-grade inflammation, and nutritional inadequacies. Prompt and accurate diagnosis is critical to facilitate early implementation of preventive measures and to guide personalised, evidence-based therapeutic interventions. Current management strategies are centred on a multidisciplinary approach combining pharmacologic treatment of osteoporosis, targeted physical activity, and comprehensive nutritional optimisation to delay or halt the progression of this debilitating condition.</p>

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Osteosarcopenia: una sindrome endocrino-geriatrica

  • 期刊论文

  • 发表日期：

    2026年1月15日

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  • Filippo Niccolai,
  • Maria Napoleone,
  • Gianluca Bufi,
  • Martina Lombardi,
  • Tessa Mazzarone,
  • Valeria Calsolaro,
  • Alessandro Mengozzi,
  • Federica Saponaro,
  • Agostino Virdis,
  • Fabio Monzani

摘要

Osteosarcopenia is a recently recognised geriatric syndrome characterised by the concurrent manifestation of osteoporosis and sarcopenia – two interrelated conditions that synergistically exacerbate frailty, disability, and mortality in the ageing population. The aetiology of osteosarcopenia is multifactorial, involving intricate interplays among genetic susceptibility, endocrine dysregulation, chronic low-grade inflammation, and nutritional inadequacies. Prompt and accurate diagnosis is critical to facilitate early implementation of preventive measures and to guide personalised, evidence-based therapeutic interventions. Current management strategies are centred on a multidisciplinary approach combining pharmacologic treatment of osteoporosis, targeted physical activity, and comprehensive nutritional optimisation to delay or halt the progression of this debilitating condition.