Scholarlink

<p>Neuroendocrine tumours (NEN) are an heterogeneous group of rare and tendentially indolent neoplasms. Metastases from neuroendocrine tumours often transcend their sites of origin. The most frequent sites are liver, lymph nodes, lungs and bone. Bone metastases (BM), which were once thought to be extremely rare, have now increased thanks to improved imaging techniques, including PET Ga 68. Usually indolent, they can however lead to pain, pathological fractures and spinal cord compression. The presence of MO at diagnosis worsens the disease prognosis. Management requires an integrated approach with systemic therapies, radiotherapy, PRRT and anti-resorptive agents. Although specific guidelines are lacking, increased awareness among experts and targeted screening strategies are crucial for improved management.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Metastasi ossee nei tumori neuroendocrini: epidemiologia, presentazione clinica e risvolti terapeutici

  • 期刊论文

  • 发表日期：

    2025年7月17日

查看全文
  • Elisabetta Lavezzi,
  • Simona Jaafar

摘要

Neuroendocrine tumours (NEN) are an heterogeneous group of rare and tendentially indolent neoplasms. Metastases from neuroendocrine tumours often transcend their sites of origin. The most frequent sites are liver, lymph nodes, lungs and bone. Bone metastases (BM), which were once thought to be extremely rare, have now increased thanks to improved imaging techniques, including PET Ga 68. Usually indolent, they can however lead to pain, pathological fractures and spinal cord compression. The presence of MO at diagnosis worsens the disease prognosis. Management requires an integrated approach with systemic therapies, radiotherapy, PRRT and anti-resorptive agents. Although specific guidelines are lacking, increased awareness among experts and targeted screening strategies are crucial for improved management.