Scholarlink

Purpose <p>To evaluate the oral health status of children and young adults with type 1 diabetes (T1D) compared with healthy controls (HC), and its association with clinical parameters and salivary inflammatory markers.</p> Methods <p>Seventy-two subjects with T1D and 86 HCs underwent a clinical oral examination. Salivary cytokines were measured using multiplex immunoassays. Differences between oral conditions, clinical parameters and cytokines were tested and mediation models were used to evaluate the role of T1D and HbA1c.</p> Results <p>T1D subjects showed significantly higher frequencies of caries (67% <i>vs.</i> 28.5%) and gingivitis (76% <i>vs.</i> 42%) compared with HC (p &lt; 0.001), independently by oral hygiene habits. In T1D, the presence of caries and gingivitis is associated with unfavourable clinical outcomes, including higher HbA1c, triglycerides, and urinary creatinine (p-value &lt; 0.05). Salivary cytokine profile differed according to oral condition: caries was associated with reduced IL-4, IL-10, and IFN-γ; gingivitis with elevated IL-1Ra and RANTES; and both conditions with increased IL-1β (p-value &lt; 0.05). Mediation analyses revealed no significant influence of HbA1c.</p> Conclusion <p>Children and young adults with T1D show a higher prevalence of oral diseases and distinct inflammatory profile, regardless of metabolic status. These findings call for routine integration of oral assessment in T1D management.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Oral health and salivary inflammatory markers in children and adolescents with type 1 diabetes: A cross-sectional study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月8日

查看全文
  • Eulalia Catamo,
  • Gianluca Tornese,
  • Chiara Navarra,
  • Luana Aldegheri,
  • Nunzia Zanotta,
  • Manola Comar,
  • Milena Cadenaro,
  • Antonietta Robino

摘要

Purpose

To evaluate the oral health status of children and young adults with type 1 diabetes (T1D) compared with healthy controls (HC), and its association with clinical parameters and salivary inflammatory markers.

Methods

Seventy-two subjects with T1D and 86 HCs underwent a clinical oral examination. Salivary cytokines were measured using multiplex immunoassays. Differences between oral conditions, clinical parameters and cytokines were tested and mediation models were used to evaluate the role of T1D and HbA1c.

Results

T1D subjects showed significantly higher frequencies of caries (67% vs. 28.5%) and gingivitis (76% vs. 42%) compared with HC (p < 0.001), independently by oral hygiene habits. In T1D, the presence of caries and gingivitis is associated with unfavourable clinical outcomes, including higher HbA1c, triglycerides, and urinary creatinine (p-value < 0.05). Salivary cytokine profile differed according to oral condition: caries was associated with reduced IL-4, IL-10, and IFN-γ; gingivitis with elevated IL-1Ra and RANTES; and both conditions with increased IL-1β (p-value < 0.05). Mediation analyses revealed no significant influence of HbA1c.

Conclusion

Children and young adults with T1D show a higher prevalence of oral diseases and distinct inflammatory profile, regardless of metabolic status. These findings call for routine integration of oral assessment in T1D management.