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Purpose <p>Increasing evidence suggests a role of 11-oxygenated adrenal androgens (11-OxyA) (11-ketotestosterone, 11KT; 11β-hydroxytestosterone, 11OHT; 11-ketoandrostenedione, 11KA4; 11β-hydroxyandrostenedione, 11OHA4) in several hyperandrogenic disorders. This study aimed to describe distributions of 11-OxyA in a healthy young adult population and explore the relation between hormonal contraceptives and 11-OxyA.</p> Methods <p>This study utilized cross-sectional data from the third Fit Futures Study conducted in Norway. 11-OxyA in fasting blood samples were analyzed by liquid chromatography tandem mass spectrometry technique (LC-MS/MS). Contraceptive use was registered and categorized as combined hormonal contraceptives (CHC) or gestagen-only contraceptives.&#xa0;Descriptive statistics were used to report 11-OxyA distributions. Independent t-tests and ANOVA were used to compare biomarker concentrations between groups.</p> Results <p>The study included 289 males and 337 females with median age of 27 years. Males had 9–30% higher 11-OxyA concentrations than females (all p’s &lt; 0.01). Among the females, 25.5% used CHC, 36.7% used gestagen-only contraceptives, and 37.8% used non-hormonal contraceptives or no contraceptives. As concentrations of 11-OxyA in gestagen-only contraceptives users were similar to non-users, these groups were combined. CHC users had 25–29% lower concentrations of 11KT, 11OHT, and 11KA4 than non-CHC users (all p’s &lt; 0.001). After exclusion of CHC users, sex differences attenuated and was no longer significant for 11KT.</p> Conclusion <p>Females had lower concentrations of 11-OxyA than males, partly explained by use of CHC, as users had significantly lower concentrations of 11-OxyA than non-CHC users, except 11OHA4. These findings suggest an additional mechanism for CHC in treatment of hyperandrogenic conditions, in which 11-OxyA are elevated.</p>

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11-oxygenated androgens in healthy young adults: Does use of hormonal contraceptives matter? The Fit Futures Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月6日

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  • Torkild Pettersen,
  • Ole-Martin Fuskevåg,
  • Yngve A. Figenschau,
  • Elin K. Evensen,
  • Anne-Sofie Furberg,
  • Anne Winther,
  • Guri Grimnes

摘要

Purpose

Increasing evidence suggests a role of 11-oxygenated adrenal androgens (11-OxyA) (11-ketotestosterone, 11KT; 11β-hydroxytestosterone, 11OHT; 11-ketoandrostenedione, 11KA4; 11β-hydroxyandrostenedione, 11OHA4) in several hyperandrogenic disorders. This study aimed to describe distributions of 11-OxyA in a healthy young adult population and explore the relation between hormonal contraceptives and 11-OxyA.

Methods

This study utilized cross-sectional data from the third Fit Futures Study conducted in Norway. 11-OxyA in fasting blood samples were analyzed by liquid chromatography tandem mass spectrometry technique (LC-MS/MS). Contraceptive use was registered and categorized as combined hormonal contraceptives (CHC) or gestagen-only contraceptives. Descriptive statistics were used to report 11-OxyA distributions. Independent t-tests and ANOVA were used to compare biomarker concentrations between groups.

Results

The study included 289 males and 337 females with median age of 27 years. Males had 9–30% higher 11-OxyA concentrations than females (all p’s < 0.01). Among the females, 25.5% used CHC, 36.7% used gestagen-only contraceptives, and 37.8% used non-hormonal contraceptives or no contraceptives. As concentrations of 11-OxyA in gestagen-only contraceptives users were similar to non-users, these groups were combined. CHC users had 25–29% lower concentrations of 11KT, 11OHT, and 11KA4 than non-CHC users (all p’s < 0.001). After exclusion of CHC users, sex differences attenuated and was no longer significant for 11KT.

Conclusion

Females had lower concentrations of 11-OxyA than males, partly explained by use of CHC, as users had significantly lower concentrations of 11-OxyA than non-CHC users, except 11OHA4. These findings suggest an additional mechanism for CHC in treatment of hyperandrogenic conditions, in which 11-OxyA are elevated.