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Objectives <p>The role of oxylipins in type 2 diabetes (T2D) with obesity remains poorly understood. This study aimed to characterize oxylipin profiles in T2D patients with obesity, identify associations with pancreatic beta-cell function, and suggest potential therapeutic targets.</p> Methods <p>We recruited first-onset T2D patients with obesity (OB group, <i>n</i> = 15) and normal-weight T2D patients (NW group, <i>n</i> = 15), matched by gender, age, and blood lipid levels. Serum samples were collected in a fasting state before medication. Oxylipin profiling was analyzed using liquid chromatography-tandem mass spectrometry, detecting 120 oxylipins. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to analyze oxylipin profiles, and Pearson’s correlation coefficients assessed the relationship between oxylipin concentrations and clinical parameters.</p> Results <p>Six oxylipins with variable importance in projection (VIP &gt; 1) and <i>p</i> &lt; 0.05 were significantly different between OB and NW groups. Five oxylipins (13-oxoODE, 12,13-EpOME, 15-keto-PGE2, 9,10-EpOME, 16(17)-EpDPE) were elevated in the OB group, while 2,3-dinor-8-iso-PGF2α was reduced. Correlation analysis revealed that 13-oxoODE, 15-keto-PGE2, and 16(17)-EpDPE levels positively correlated with BMI, visceral adipose tissue (VAT), and pancreatic beta-cell function.</p> Conclusions <p>Oxylipin profiling in first-onset T2D patients with obesity revealed that altered oxylipin metabolism, particularly linoleic acid pathways, is closely linked to pancreatic beta-cell dysfunction. These findings suggest potential biomarkers for therapeutic intervention.</p>

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Oxidized metabolites of linoleic acid as biomarkers of pancreatic beta-cell function in the first-onset type 2 diabetic patients with obesity

  • 期刊论文

  • 发表日期：

    2026年1月5日

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  • Xiaoxu Ge,
  • Jiajia Wang,
  • Juan Du,
  • Wenyi Li,
  • Liuqing Xi,
  • Xiaohong Jiang,
  • Wenfang Peng,
  • Xingyun Wang,
  • Xirong Guo,
  • Shan Huang

摘要

Objectives

The role of oxylipins in type 2 diabetes (T2D) with obesity remains poorly understood. This study aimed to characterize oxylipin profiles in T2D patients with obesity, identify associations with pancreatic beta-cell function, and suggest potential therapeutic targets.

Methods

We recruited first-onset T2D patients with obesity (OB group, n = 15) and normal-weight T2D patients (NW group, n = 15), matched by gender, age, and blood lipid levels. Serum samples were collected in a fasting state before medication. Oxylipin profiling was analyzed using liquid chromatography-tandem mass spectrometry, detecting 120 oxylipins. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to analyze oxylipin profiles, and Pearson’s correlation coefficients assessed the relationship between oxylipin concentrations and clinical parameters.

Results

Six oxylipins with variable importance in projection (VIP > 1) and p < 0.05 were significantly different between OB and NW groups. Five oxylipins (13-oxoODE, 12,13-EpOME, 15-keto-PGE2, 9,10-EpOME, 16(17)-EpDPE) were elevated in the OB group, while 2,3-dinor-8-iso-PGF2α was reduced. Correlation analysis revealed that 13-oxoODE, 15-keto-PGE2, and 16(17)-EpDPE levels positively correlated with BMI, visceral adipose tissue (VAT), and pancreatic beta-cell function.

Conclusions

Oxylipin profiling in first-onset T2D patients with obesity revealed that altered oxylipin metabolism, particularly linoleic acid pathways, is closely linked to pancreatic beta-cell dysfunction. These findings suggest potential biomarkers for therapeutic intervention.