<p>The murder of Black women in the United States (U.S.) is a major public health concern that has received minimal attention. Black women in the U.S., including Black transgender women, are at increased risk for murder, including but not limited to intimate partner homicide (IPH) and homicide by police, relative to their White counterparts. Stereotypes of Black women may reduce inhibitions towards violence against this group by both intimate partners and police officers. Structural inequalities that place Black communities at increased risk for exposure to violence and heightened policing also contribute to existing disparities. The disproportionate murder of Black women significantly affects their families and communities. Despite the sheer magnitude and persistence of these disparities, there have been limited efforts to raise awareness of this significant public health concern. Culturally informed services tailored towards Black men have potential for reducing IPH. Policies that foster the development of Black communities and disrupt the impact of systematic racism are also necessary to reduce risk for Black women. Here we place an urgent call to action to save the lives of Black women in the U.S.</p>