<p>North American Indigenous (NAI) adolescents experience disproportionately high rates of alcohol-related consequences and racial discrimination but report similar rates of alcohol consumption as other racial/ethnic groups. Racial discrimination serves a deleterious role on adolescent development and well-being. To test if NAI adolescents’ disproportionate rates of alcohol-related consequences are related to the negative effects of racial discrimination, the present study examined whether racial discrimination moderates the association between alcohol consumption and alcohol-related consequences among NAI adolescents. Participants were First Nations adolescents from reserve communities in Eastern Canada (<i>n</i> = 60, <i>M</i>_<i>age</i> = 15.9, 53.3% female) who reported lifetime alcohol use. The interaction of alcohol consumption by racial discrimination was statistically significantly and positively associated with alcohol-related consequences (<i>b</i> = 1.28, <i>SE</i> = 0.56, <i>p</i> = .025). Simple slopes analyses revealed that alcohol consumption was significantly positively related to alcohol-related consequences for those reporting high levels of racial discrimination (1 <i>SD</i> above the mean; <i>b</i> = 1.19, <i>SE</i> = 0.27, <i>p</i> &lt; .001), but not for those reporting relatively low levels of racial discrimination (1 <i>SD</i> below the mean). Thus, racial discrimination may contribute to the disproportionate rate of consequences related to alcohol consumption experienced by NAI adolescents. These findings suggest the need for systems-level interventions to address racial discrimination and prejudice, as well as individual-focused interventions to increase factors previously found to protect against the negative effects of racial discrimination (e.g., racial-ethnic socialization, self-compassion).</p>