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Background <p>Triple-negative breast cancer (TNBC) accounts for 40–50% of breast cancers in young Black women. Black women have an increased risk of death due to TNBC than White women; whether age contributes to worse outcomes in the setting of a high-risk tumor subtype is unclear.</p> Methods <p>Our retrospective review of an institutional database identified Black women with operable TNBC from 2005 to 2020. Clinicopathologic, treatment, and outcome variables in women aged &lt; 40 (young adults [YAs] cohort) were compared to those ≥ 40&#xa0;years using Cox proportional hazard models. Kaplan–Meier method estimated overall survival (OS) and breast cancer–specific survival (BCSS).</p> Results <p>We identified 397 Black women with a median age of 55 (range 23–88); 39 (9.8%) were &lt; 40 and 358 (90.2%) were ≥ 40. The YA cohort were more likely to have a <i>BRCA</i> mutation and present with a physical finding and more advanced clinical stage (all <i>p</i> &lt; 0.01). Compared with women ≥ 40&#xa0;years, those &lt; 40 were more likely to receive mastectomy (61.5% vs. 31.3%; <i>p</i> &lt; 0.001) and neoadjuvant chemotherapy (46.2% vs. 26.7%; <i>p</i> = 0.05), and not receive adjuvant radiotherapy (35.9% vs. 18.8%; <i>p</i> = 0.008). At a median follow-up of 6.2&#xa0;years, the 5-year OS and BCSS rates were 81.2% and 84.0% in women &lt; 40&#xa0;years old, and 80.9% and 85.3% in those ≥ 40 (<i>p</i> = 0.45 and <i>p</i> = 0.75, respectively).</p> Conclusion <p>Young age at diagnosis in Black women with TNBC was not an independent predictor of locoregional recurrence, distant recurrence, OS, or BCSS despite being associated with higher stage of disease.</p>

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Triple-Negative Breast Cancer, Recurrence, and Survival Outcomes in Young Black Women

  • 期刊论文

  • 发表日期：

    2025年10月2日

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  • Regina Matar-Ujvary,
  • Sara P. Myers,
  • Simran Malhotra,
  • Varadan Sevilimedu,
  • Mary L. Gemignani

摘要

Background

Triple-negative breast cancer (TNBC) accounts for 40–50% of breast cancers in young Black women. Black women have an increased risk of death due to TNBC than White women; whether age contributes to worse outcomes in the setting of a high-risk tumor subtype is unclear.

Methods

Our retrospective review of an institutional database identified Black women with operable TNBC from 2005 to 2020. Clinicopathologic, treatment, and outcome variables in women aged < 40 (young adults [YAs] cohort) were compared to those ≥ 40 years using Cox proportional hazard models. Kaplan–Meier method estimated overall survival (OS) and breast cancer–specific survival (BCSS).

Results

We identified 397 Black women with a median age of 55 (range 23–88); 39 (9.8%) were < 40 and 358 (90.2%) were ≥ 40. The YA cohort were more likely to have a BRCA mutation and present with a physical finding and more advanced clinical stage (all p < 0.01). Compared with women ≥ 40 years, those < 40 were more likely to receive mastectomy (61.5% vs. 31.3%; p < 0.001) and neoadjuvant chemotherapy (46.2% vs. 26.7%; p = 0.05), and not receive adjuvant radiotherapy (35.9% vs. 18.8%; p = 0.008). At a median follow-up of 6.2 years, the 5-year OS and BCSS rates were 81.2% and 84.0% in women < 40 years old, and 80.9% and 85.3% in those ≥ 40 (p = 0.45 and p = 0.75, respectively).

Conclusion

Young age at diagnosis in Black women with TNBC was not an independent predictor of locoregional recurrence, distant recurrence, OS, or BCSS despite being associated with higher stage of disease.