Scholarlink

Objective <p>To test whether race/ethnicity affects stage or grade distribution at upper tract urothelial carcinoma (UTUC) diagnosis.</p> Methods <p>Within the Surveillance, Epidemiology, and End Results (SEER) database 2004–2020, UTUC patients were identified. Multivariable logistic regression models tested for the association between race/ethnicity and stage as well as grade at diagnosis according to renal pelvis vs. ureteral origin. Stage at presentation was defined as (i) metastatic stage (T<sub>any</sub>N<sub>any</sub>M<sub>1</sub>) and (ii) advanced stage (locoregional or metastatic (T<sub>3-4</sub>N<sub>0-2</sub>M<sub>0-1</sub>)).</p> Results <p>Of 14,384 UTUC patients, 8926 (62%) were renal pelvis. Of renal pelvis UTUC patients, 7064 (79%) were Caucasian, 797 (9%) Hispanic, 623 (7%) Asian Pacific Islander (API), and 442 (5%) African American (AA). Relative to Caucasians, API (odd ratio (OR) 1.85, 95% confidence interval (CI) 1.44–2.37, <i>p</i> &lt; 0.001) and AA (OR 1.37, 95% CI 1.02–1.83, <i>p</i> = 0.03) patients more frequently harbored metastatic stage. APIs also more frequently harbored advanced (OR 1.33, 95% CI 1.11–1.60, <i>p</i> = 0.002) stage and high (OR 1.33, 95% CI 1.07–1.67, <i>p</i> = 0.01) grade. Of 5458 (38%) ureteral UTUC patients, 4360 (80%) were Caucasian, 362 (7%) Hispanic, 509 (9%) API, and 227 (4%) AA. Relative to Caucasians, Hispanic (OR 1.45, 95% CI 1.01–2.05, <i>p</i> = 0.03) patients more frequently harbored metastatic stage. APIs also more frequently harbored advanced stage (OR 1.22, 95% CI 1.02–1.47, <i>p</i> = 0.03) and high (OR 1.94, 95% CI 1.49–2.55, <i>p</i> &lt; 0.001) grade.</p> Conclusions <p>Race/ethnicity other than Caucasian, such as API and Hispanic, may predispose to higher odds of metastatic (T<sub>any</sub>N<sub>any</sub>M<sub>1</sub>) or advanced (T<sub>3-4</sub>N<sub>0-2</sub>M<sub>0-1</sub>) stages as well as to higher grade at initial diagnosis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Non-Caucasian Race/Ethnicity Predisposes to Unfavorable Stage and Grade at Upper Tract Urothelial Carcinoma Diagnosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月9日

查看全文
  • Francesco Di Bello,
  • Mario de Angelis,
  • Carolin Siech,
  • Natali Rodriguez Peñaranda,
  • Zhe Tian,
  • Jordan A. Goyal,
  • Claudia Collà Ruvolo,
  • Gianluigi Califano,
  • Massimiliano Creta,
  • Fred Saad,
  • Shahrokh F. Shariat,
  • Alberto Briganti,
  • Felix K. H. Chun,
  • Salvatore Micali,
  • Nicola Longo,
  • Pierre I. Karakiewicz

摘要

Objective

To test whether race/ethnicity affects stage or grade distribution at upper tract urothelial carcinoma (UTUC) diagnosis.

Methods

Within the Surveillance, Epidemiology, and End Results (SEER) database 2004–2020, UTUC patients were identified. Multivariable logistic regression models tested for the association between race/ethnicity and stage as well as grade at diagnosis according to renal pelvis vs. ureteral origin. Stage at presentation was defined as (i) metastatic stage (TanyNanyM1) and (ii) advanced stage (locoregional or metastatic (T3-4N0-2M0-1)).

Results

Of 14,384 UTUC patients, 8926 (62%) were renal pelvis. Of renal pelvis UTUC patients, 7064 (79%) were Caucasian, 797 (9%) Hispanic, 623 (7%) Asian Pacific Islander (API), and 442 (5%) African American (AA). Relative to Caucasians, API (odd ratio (OR) 1.85, 95% confidence interval (CI) 1.44–2.37, p < 0.001) and AA (OR 1.37, 95% CI 1.02–1.83, p = 0.03) patients more frequently harbored metastatic stage. APIs also more frequently harbored advanced (OR 1.33, 95% CI 1.11–1.60, p = 0.002) stage and high (OR 1.33, 95% CI 1.07–1.67, p = 0.01) grade. Of 5458 (38%) ureteral UTUC patients, 4360 (80%) were Caucasian, 362 (7%) Hispanic, 509 (9%) API, and 227 (4%) AA. Relative to Caucasians, Hispanic (OR 1.45, 95% CI 1.01–2.05, p = 0.03) patients more frequently harbored metastatic stage. APIs also more frequently harbored advanced stage (OR 1.22, 95% CI 1.02–1.47, p = 0.03) and high (OR 1.94, 95% CI 1.49–2.55, p < 0.001) grade.

Conclusions

Race/ethnicity other than Caucasian, such as API and Hispanic, may predispose to higher odds of metastatic (TanyNanyM1) or advanced (T3-4N0-2M0-1) stages as well as to higher grade at initial diagnosis.