Scholarlink

Purpose of Review <p>Host defense peptides (HDPs) have emerged as promising candidates with multifaceted roles in enhancing host immunity against a variety of microbial threats. This review aims to examine the immunomodulatory potential and inducibility of HDPs, providing insights into their ability to enhance host immunity and address the challenge of multidrug-resistant bacteria.</p> Recent Findings <p>Data were extracted from a total of 31 publications. A total of nine (9) Host Defense Peptides (HDPs) were identified from various microorganisms, exhibiting diverse antimicrobial activities. Additionally, eight (8) HDPs were sourced from plants, while ten (10) experimental animal-derived HDPs were also documented. Data also showed that synergistic combinations of HDPs with antibiotics or antivirals enhanced efficacy, including a 50% reduction in viral load with Human Beta-Defensin 2 (hBD-2) and acyclovir and a 60% decrease in viral replication with Defensin 1 and ribavirin.</p> Summary <p>The promising nature of these peptides as alternatives for combating infections is evident, holding significant potential to mitigate the emergence of antimicrobial resistance (AMR).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparative Analysis and Integration of Host Defence Peptides with Conventional Therapies: A systematic review

  • 期刊论文

  • 发表日期：

    2025年3月8日

查看全文
  • Brice Boris Legba,
  • Kévin Sintondji,
  • Victorien Dougnon,
  • Shymaa Enany

摘要

Purpose of Review

Host defense peptides (HDPs) have emerged as promising candidates with multifaceted roles in enhancing host immunity against a variety of microbial threats. This review aims to examine the immunomodulatory potential and inducibility of HDPs, providing insights into their ability to enhance host immunity and address the challenge of multidrug-resistant bacteria.

Recent Findings

Data were extracted from a total of 31 publications. A total of nine (9) Host Defense Peptides (HDPs) were identified from various microorganisms, exhibiting diverse antimicrobial activities. Additionally, eight (8) HDPs were sourced from plants, while ten (10) experimental animal-derived HDPs were also documented. Data also showed that synergistic combinations of HDPs with antibiotics or antivirals enhanced efficacy, including a 50% reduction in viral load with Human Beta-Defensin 2 (hBD-2) and acyclovir and a 60% decrease in viral replication with Defensin 1 and ribavirin.

Summary

The promising nature of these peptides as alternatives for combating infections is evident, holding significant potential to mitigate the emergence of antimicrobial resistance (AMR).