<p>More than ten million people worldwide suffer a stroke each year, and one in three survivors will experience language problems, known as post-stroke aphasia. However, the literature reveals that the most severe cases of post-stroke aphasia are systematically excluded from clinical research due to the difficulty or inability of these individuals to communicate their consent. Consequently, both their physical and psychological health, as well as their inalienable rights as human beings, are severely affected. Therefore, this work aims to critically analyze the North American principlist bioethics of Beauchamp and Childress as a theoretical basis to assess the participation of individuals with severe post-stroke aphasia in clinical research and to propose a reorientation of bioethical analysis towards the principles established because of the BIOMED-II project, relatively recent in Europe. Taking the last one into consideration, and along with the most important international bioethical treaties, there seems to be sufficient justification for the participation of individuals with severe post-stroke aphasia in clinical research if its four principles are respected: the principle of autonomy, understood in line with the Kantian moral idea of treating individuals as ends in themselves, and the principles of dignity, integrity, and vulnerability.</p>