In this paper, we prove the existence and uniqueness of weak solution for a nonlinear degenerate Navier problem involving the weighted biharmonic operator of the following form: \(\begin{aligned}{} & {} \Delta \Big [\phi (z)a(z,\Delta w)\Big ]-\mathrm{{div}}\Big [ \vartheta _{1}(z)\mathcal {K}(z,\nabla w)+\vartheta _{2}(z)\mathcal {L}(z,w,\nabla w)\Big ] \\{} & {} \qquad +\vartheta _{2}(z)\mathcal {L}_{0}(z,w,\nabla w)=h_0-\sum \limits _{j=1}^{n} D_{j}h_{j} \;, \end{aligned}\) where \(\phi \) , \(\vartheta _1\) and \(\vartheta _2\) are weight functions, \(a:\overline{\mathcal {D}}\times \mathbb {R}^n\longrightarrow \mathbb {R}^n\) , \(\mathcal {K}:\mathcal {D}\times \mathbb {R}^n\longrightarrow \mathbb {R}^n\) , \(\mathcal {L}:\mathcal {D}\times \mathbb {R}\times \mathbb {R}^n\longrightarrow \mathbb {R}^n\) , and \(\mathcal {L}_0:\mathcal {D}\times \mathbb {R}\times \mathbb {R}^n\longrightarrow \mathbb {R}\) are Carathéodory applications that verified some conditions, and \(h_0\in L^1(\mathcal {D})~\) and \(h_j\in L^{p'}(\mathcal {D},\vartheta _{1}^{1-p'})(j=1,\ldots ,n)\) .