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Purpose of review <p>Zika virus (ZIKV) is a mosquito-borne flavivirus, most prevalent in tropical areas. ZIKV rose to prominence during 2015–2016 due to an outbreak in the Americas leading to the recognition of adverse outcomes with infection during pregnancy. This review highlights the advances of research a decade after this epidemic.</p> Recent Findings <p>During the last decade the epidemiology of ZIKV evolved with the incidence decreasing significantly. Critical advances have been made in the understanding pathophysiology of infection during pregnancy, the effect of prenatal ZIKV exposure in normocephalic infants, the immune response to the virus, and the challenges in vaccine development.</p> Summary <p>ZIKV remains a global public health threat. There are ongoing challenges in preparedness, post-natal sequela care, and prevention strategies. Continued research is needed to fill these gaps. </p>

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Zika Virus: Challenges and Advances on an Ongoing Threat

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月21日

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  • Diego A. Cruz-Vidal,
  • Ana M Cabal-Herrera,
  • Eduardo Lopez-Medina

摘要

Purpose of review

Zika virus (ZIKV) is a mosquito-borne flavivirus, most prevalent in tropical areas. ZIKV rose to prominence during 2015–2016 due to an outbreak in the Americas leading to the recognition of adverse outcomes with infection during pregnancy. This review highlights the advances of research a decade after this epidemic.

Recent Findings

During the last decade the epidemiology of ZIKV evolved with the incidence decreasing significantly. Critical advances have been made in the understanding pathophysiology of infection during pregnancy, the effect of prenatal ZIKV exposure in normocephalic infants, the immune response to the virus, and the challenges in vaccine development.

Summary

ZIKV remains a global public health threat. There are ongoing challenges in preparedness, post-natal sequela care, and prevention strategies. Continued research is needed to fill these gaps.