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Purpose of Review <p>Increasing evidence shows that the onset of the host cytoskeleton changes during the viral infection process. The attainment of in-depth knowledge about the molecular pathways coopted by viruses to induce cytoskeleton remodeling represents a useful premise for designing broad-spectrum antivirals.</p> Recent Findings <p>Current investigations suggest that viruses coopt specific host factors to induce cell type-related cytoskeleton modifications for successful cell invasion and viral progeny spread to neighboring cells. On the other hand, it has been argued that cytoskeletal dynamics represent the first line of innate antiviral response activation.</p> Summary <p>Here, we highlight the role of the main cytoskeletal regulatory mechanisms responsible for modulating the structure/function of specific cytoskeletal proteins at the global and local levels, which may affect the outcome of virus infection.</p>

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Highly Dynamic Cytoskeletal Networks Support Productive Viral Infection and Host Innate Immune Response Activation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月22日

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  • Flora De Conto,
  • Leonardo Mancabelli,
  • Elizabeth Prandini,
  • Marco Ventura

摘要

Purpose of Review

Increasing evidence shows that the onset of the host cytoskeleton changes during the viral infection process. The attainment of in-depth knowledge about the molecular pathways coopted by viruses to induce cytoskeleton remodeling represents a useful premise for designing broad-spectrum antivirals.

Recent Findings

Current investigations suggest that viruses coopt specific host factors to induce cell type-related cytoskeleton modifications for successful cell invasion and viral progeny spread to neighboring cells. On the other hand, it has been argued that cytoskeletal dynamics represent the first line of innate antiviral response activation.

Summary

Here, we highlight the role of the main cytoskeletal regulatory mechanisms responsible for modulating the structure/function of specific cytoskeletal proteins at the global and local levels, which may affect the outcome of virus infection.