<p>Herd immunity is a critical concept in epidemiology, describing a threshold at which a sufficient proportion of a population is immune, either through infection or vaccination, thereby preventing sustained transmission of a pathogen. In the classic susceptible-infectious-recovered (SIR) model, which has been widely used to study infectious disease dynamics, the achievement of herd immunity depends on key parameters, including the transmission rate (<InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="40574_2025_471_Article_IEq1.gif" Format="GIF" Height="17" Rendition="HTML" Resolution="72" Type="Linedraw" Width="15" /> </InlineMediaObject> <EquationSource Format="TEX">\(\beta \)</EquationSource> <EquationSource Format="MATHML"><math> <mi>β</mi> </math></EquationSource> </InlineEquation>) and the recovery rate (<InlineEquation ID="IEq2"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="40574_2025_471_Article_IEq2.gif" Format="GIF" Height="12" Rendition="HTML" Resolution="72" Type="Linedraw" Width="13" /> </InlineMediaObject> <EquationSource Format="TEX">\(\gamma \)</EquationSource> <EquationSource Format="MATHML"><math> <mi>γ</mi> </math></EquationSource> </InlineEquation>), where <InlineEquation ID="IEq3"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="40574_2025_471_Article_IEq2.gif" Format="GIF" Height="12" Rendition="HTML" Resolution="72" Type="Linedraw" Width="13" /> </InlineMediaObject> <EquationSource Format="TEX">\(\gamma \)</EquationSource> <EquationSource Format="MATHML"><math> <mi>γ</mi> </math></EquationSource> </InlineEquation> represents the inverse of the mean infectious period. While the transmission rate has received substantial attention, recent studies have underscored the significant role of <InlineEquation ID="IEq4"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="40574_2025_471_Article_IEq2.gif" Format="GIF" Height="12" Rendition="HTML" Resolution="72" Type="Linedraw" Width="13" /> </InlineMediaObject> <EquationSource Format="TEX">\(\gamma \)</EquationSource> <EquationSource Format="MATHML"><math> <mi>γ</mi> </math></EquationSource> </InlineEquation> in determining the timing and sustainability of herd immunity. Additionally, it is becoming increasingly evident that assuming <InlineEquation ID="IEq5"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="40574_2025_471_Article_IEq2.gif" Format="GIF" Height="12" Rendition="HTML" Resolution="72" Type="Linedraw" Width="13" /> </InlineMediaObject> <EquationSource Format="TEX">\(\gamma \)</EquationSource> <EquationSource Format="MATHML"><math> <mi>γ</mi> </math></EquationSource> </InlineEquation> as a constant parameter might oversimplify the dynamics, as variations in recovery times can reflect diverse biological, social, and healthcare-related factors. In this paper, we investigate how heterogeneity in the recovery rate affects herd immunity. We show empirically that the mean of the recovery rate is not a reliable metric for determining the achievement of herd immunity. Furthermore, we provide a theoretical result demonstrating that it is instead the mean recovery time, which is the mean of the inverse <InlineEquation ID="IEq6"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="40574_2025_471_Article_IEq6.gif" Format="GIF" Height="19" Rendition="HTML" Resolution="72" Type="Linedraw" Width="29" /> </InlineMediaObject> <EquationSource Format="TEX">\(1/\gamma \)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mn>1</mn> <mo stretchy="false">/</mo> <mi>γ</mi> </mrow> </math></EquationSource> </InlineEquation> of the recovery rate that is critical in deciding whether herd immunity is achievable within the SIR framework. A similar result is proved for the SEIR model. These insights have significant implications for public health interventions and theoretical modeling of epidemic dynamics.</p>

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The impact of recovery rate heterogeneity in achieving herd immunity

  • Gabriel Turinici

摘要

Herd immunity is a critical concept in epidemiology, describing a threshold at which a sufficient proportion of a population is immune, either through infection or vaccination, thereby preventing sustained transmission of a pathogen. In the classic susceptible-infectious-recovered (SIR) model, which has been widely used to study infectious disease dynamics, the achievement of herd immunity depends on key parameters, including the transmission rate ( \(\beta \) β ) and the recovery rate ( \(\gamma \) γ ), where \(\gamma \) γ represents the inverse of the mean infectious period. While the transmission rate has received substantial attention, recent studies have underscored the significant role of \(\gamma \) γ in determining the timing and sustainability of herd immunity. Additionally, it is becoming increasingly evident that assuming \(\gamma \) γ as a constant parameter might oversimplify the dynamics, as variations in recovery times can reflect diverse biological, social, and healthcare-related factors. In this paper, we investigate how heterogeneity in the recovery rate affects herd immunity. We show empirically that the mean of the recovery rate is not a reliable metric for determining the achievement of herd immunity. Furthermore, we provide a theoretical result demonstrating that it is instead the mean recovery time, which is the mean of the inverse \(1/\gamma \) 1 / γ of the recovery rate that is critical in deciding whether herd immunity is achievable within the SIR framework. A similar result is proved for the SEIR model. These insights have significant implications for public health interventions and theoretical modeling of epidemic dynamics.