Purpose of review <p>To evaluate the recent literature on differential exposure to and health risks from wildfire smoke across subpopulations, whether wildfire-derived PM_2.5 affects health differently from non-wildfire-derived PM_2.5, and how wildfire smoke composition affects health.</p> Recent Findings <p>We found inconsistent evidence of differential exposure to and health risks from wildfire PM_2.5 by population subgroups. This could be due to variation in wildfire PM_2.5 infiltration into buildings and ability to take individual protective actions, both of which have been noted to be related to socio-economic status in the recent scientific literature. Respiratory health endpoints have been the most consistent and commonly evaluated health outcome in studies of wildfire smoke; additional research is needed to resolve conflicting findings for non-respiratory health outcomes (e.g., cardiovascular disease). Although some recent studies have documented larger health risks from wildfire-derived as compared to non-wildfire-derived PM_2.5, we document how further research could evaluate whether these findings are confounded by type of fuel burned, due to methodological concerns, or are true. We also conclude that more research is necessary to elucidate potential differences in health risks of constituents of wildfire smoke other than PM_2.5 or from burning of different fuels.</p> Summary <p>Wildfire smoke is projected to continue to increase. We encourage future research to move away from further documentation of respiratory health impacts of wildfire smoke, which has been very well established, into studies of other health endpoints that have been less well studied to date, more exploration into health effects from wildfire smoke constituents other than PM2.5 and from different types of fires (i.e., wildland urban interface (WUI) fires versus wildland fires), and additional exploration of remaining uncertainties with a goal of further supporting public health protection from wildfire smoke.</p>