Purpose of Review <p>This review explored atopic dermatitis (AD)-associated skin infections, and highlighted the importance of microbiome in understanding and treating these infections.</p> Recent Findings <p>AD skin is characterized by cutaneous dysbiosis and recurrent microbial skin infections caused by various microorganisms, including <i>S</i>. <i>aureus</i>, <i>Malassezia</i>, and viruses. The colonization of <i>S. aureus</i> on AD skin exacerbates the disease by contributing to skin dysbiosis, allergen sensitization, and T helper (Th)2/Th17 immune responses. In particular, the complex relationships within the skin microbiome, such as <i>S. aureus</i>, play a crucial role in the pathogenesis, progression, and exacerbation of AD. Moreover, α-toxin, a common <i>staphylococcal</i> toxin, has been found to increase herpes simplex virus in keratinocytes, potentially enhancing HSV skin infections in AD.</p> Summary <p>Microbial skin infections contribute a critical role in the development and exacerbation of AD. Understanding the skin microbiome in AD suggests promising strategies for targeting skin infections as part of AD treatment.</p>