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Background <p>Statins are used for cardiovascular prevention, but their potential impact on muscle health in adults aged ≥ 75 years remains unclear.</p> Aims <p>To assess whether statin use is associated with adverse changes in muscle strength, skeletal muscle mass, and physical performance in older adults.</p> Methods <p>Data were drawn from the SCOPE study including 2,282 participants aged ≥ 75 years with complete baseline data on statin use and muscle outcomes. Muscle strength was assessed via handgrip strength, muscle mass via skeletal muscle index (SMI), and physical performance via the Short Physical Performance Battery (SPPB). Outcomes were measured at baseline and after two years. Associations with statin use were analysed cross-sectionally and longitudinally, stratified by sex, and adjusted for confounders.</p> Results <p>At baseline, 1,107 participants (48.5%) used statins (median age 79 years). Cross-sectional analyses showed no association between statin use and handgrip strength, SMI, or SPPB scores in either sex. Over two years, there were no significant between-group differences in changes over time in handgrip strength (men: − 3.1 vs. − 2.6&#xa0;kg, <i>p</i> = 0.8; women: − 1.5 vs. − 2.5&#xa0;kg, <i>p</i> = 0.6), SMI (men: +1.0 vs. − 0.6&#xa0;kg/m², <i>p</i> = 0.1; women: +0.4 vs. − 0.1&#xa0;kg/m², <i>p</i> = 0.4), or risk of SPPB decline (men: OR 1.3, 95% CI 0.9–1.8; women: OR 1.0, 95% CI 0.8–1.4).</p> Discussion <p>These findings support muscular safety of statins in well-functioning older adults, reducing concerns about potential harm.</p> Conclusions <p>In this large cohort of adults aged ≥ 75 years, statin use was not associated with adverse changes in muscle strength, muscle mass, or physical performance over two years.</p>

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Statin use does not impair muscle health in older adults: findings from the SCOPE study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月20日

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  • Seyedeh Dalia Fazel,
  • Lisanne Tap,
  • Paolo Fabbietti,
  • Andrea Corsonello,
  • Robert Kob,
  • Cornel C. Sieber,
  • Regina Roller-Wirnsberger,
  • Gerhard Wirnsberger,
  • Ronit Ben-Romano,
  • Itshak Melzer,
  • Tomasz Kostka,
  • Agnieszka Guligowska,
  • Axel C. Carlsson,
  • Francesc Formiga,
  • Rafael Moreno-González,
  • Johan Ärnlöv,
  • Fabrizia Lattanzio,
  • Francesco Mattace-Raso

摘要

Background

Statins are used for cardiovascular prevention, but their potential impact on muscle health in adults aged ≥ 75 years remains unclear.

Aims

To assess whether statin use is associated with adverse changes in muscle strength, skeletal muscle mass, and physical performance in older adults.

Methods

Data were drawn from the SCOPE study including 2,282 participants aged ≥ 75 years with complete baseline data on statin use and muscle outcomes. Muscle strength was assessed via handgrip strength, muscle mass via skeletal muscle index (SMI), and physical performance via the Short Physical Performance Battery (SPPB). Outcomes were measured at baseline and after two years. Associations with statin use were analysed cross-sectionally and longitudinally, stratified by sex, and adjusted for confounders.

Results

At baseline, 1,107 participants (48.5%) used statins (median age 79 years). Cross-sectional analyses showed no association between statin use and handgrip strength, SMI, or SPPB scores in either sex. Over two years, there were no significant between-group differences in changes over time in handgrip strength (men: − 3.1 vs. − 2.6 kg, p = 0.8; women: − 1.5 vs. − 2.5 kg, p = 0.6), SMI (men: +1.0 vs. − 0.6 kg/m², p = 0.1; women: +0.4 vs. − 0.1 kg/m², p = 0.4), or risk of SPPB decline (men: OR 1.3, 95% CI 0.9–1.8; women: OR 1.0, 95% CI 0.8–1.4).

Discussion

These findings support muscular safety of statins in well-functioning older adults, reducing concerns about potential harm.

Conclusions

In this large cohort of adults aged ≥ 75 years, statin use was not associated with adverse changes in muscle strength, muscle mass, or physical performance over two years.