Scholarlink

Objective <p>Currently, the association of sarcopenic obesity (SO) with cognitive dysfunction and dementia remains unclear. This study aims to investigate their potential association.</p> Materials and methods <p>PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov were systematically searched until 30 December 2024. Observational studies investigating the association of SO with cognitive dysfunction and dementia were included. A random-effects model was applied for meta-analysis.</p> Results <p>Seventeen studies with 274,996 participants were included, of which 11 were included in quantitative analyses. The pooled odds ratio for cognitive dysfunction in patients with SO versus non-SO was 1.71 (95% CI: 1.39–2.11, <i>p</i> &lt; 0.001, I<sup>2</sup> = 90.7%). Subgroup analyses showed consistent associations across study design, geographic region, cognitive dysfunction subtypes, and obesity criteria. Significant results were also observed in males (OR = 1.80, 95% CI: 1.07–3.03, <i>p</i> = 0.028), general populations (OR = 1.95, 95% CI: 1.50–2.54, <i>p</i> &lt; 0.001), sarcopenia defined by muscle function and/or mass (OR = 1.67, 95% CI: 1.35–2.07, <i>p</i> &lt; 0.001) or muscle function alone (OR = 2.31, 95% CI: 1.14–4.69, <i>p</i> = 0.020), and cognitive assessment via clinical records (OR = 1.68, 95% CI: 1.21–2.33, <i>p</i> = 0.002) or scales (OR = 1.74, 95% CI: 1.37–2.21, <i>p</i> &lt; 0.001).</p> Conclusions <p>SO appears associated with cognitive dysfunction. However, due to high heterogeneity, very low certainty of evidence, and potential biases, these results should be interpreted cautiously. Future high-quality prospective studies are needed to validate this conclusion.</p> <p>PROSPERO registration number: CRD420251011745.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association of sarcopenic obesity with cognitive dysfunction and dementia: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月6日

查看全文
  • Chunbian Tang,
  • Ying Song,
  • Fengran Tao,
  • Jiayi Hao,
  • Li Yan,
  • Xiuxia Shi,
  • Runnan Pei,
  • Baoqi Zeng

摘要

Objective

Currently, the association of sarcopenic obesity (SO) with cognitive dysfunction and dementia remains unclear. This study aims to investigate their potential association.

Materials and methods

PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov were systematically searched until 30 December 2024. Observational studies investigating the association of SO with cognitive dysfunction and dementia were included. A random-effects model was applied for meta-analysis.

Results

Seventeen studies with 274,996 participants were included, of which 11 were included in quantitative analyses. The pooled odds ratio for cognitive dysfunction in patients with SO versus non-SO was 1.71 (95% CI: 1.39–2.11, p < 0.001, I2 = 90.7%). Subgroup analyses showed consistent associations across study design, geographic region, cognitive dysfunction subtypes, and obesity criteria. Significant results were also observed in males (OR = 1.80, 95% CI: 1.07–3.03, p = 0.028), general populations (OR = 1.95, 95% CI: 1.50–2.54, p < 0.001), sarcopenia defined by muscle function and/or mass (OR = 1.67, 95% CI: 1.35–2.07, p < 0.001) or muscle function alone (OR = 2.31, 95% CI: 1.14–4.69, p = 0.020), and cognitive assessment via clinical records (OR = 1.68, 95% CI: 1.21–2.33, p = 0.002) or scales (OR = 1.74, 95% CI: 1.37–2.21, p < 0.001).

Conclusions

SO appears associated with cognitive dysfunction. However, due to high heterogeneity, very low certainty of evidence, and potential biases, these results should be interpreted cautiously. Future high-quality prospective studies are needed to validate this conclusion.

PROSPERO registration number: CRD420251011745.