Scholarlink

Aims <p>Building upon established short-term benefits, this study aimed to assess Tai Chi’s durability for preserving global and domain-specific cognition in older adults (≥ 60 years) with type 2 diabetes and mild cognitive impairment (T2D-MCI), compared to fitness walking and health education.</p> Methods <p>Participants (<i>n</i> = 328) were randomized 1:1:1 to Tai Chi, fitness walking, or health education groups, completing 24-week interventions. Cognitive outcomes—global cognition (Montreal Cognitive Assessment, MoCA), executive function, attention, visuospatial ability, and language fluency—were evaluated at baseline, 24 weeks(post-intervention), 36 weeks, and 2 years. Linear mixed models analyzed group-by-time interactions, while time-dependent Cox regression quantified minimal clinically important difference (MCID) attainment (MoCA improvement ≥ 4 points).</p> Results <p>At 2-year follow-up, linear mixed models revealed significant group-by-time interactions for MoCA (<i>p</i> &lt; 0.001). The Tai Chi group showed greater MoCA improvement versus health education (mean difference: 1.8, 95% CI 0.3–3.3, <i>p</i> = 0.016). Crucially, 49.8% of Tai Chi practitioners achieved MCID—nearly double the probability of health education (HR 2.0, 95% CI 1.4–2.8, <i>p</i> &lt; 0.001) and exceeding fitness walking (HR 1.7, 95% CI 1.2–2.4; <i>p</i> = 0.005). Tai Chi selectively enhanced executive function (shorter Stroop reaction times vs. health education, <i>p</i> &lt; 0.05; fewer color-word errors vs. fitness walking, <i>p</i> = 0.049) and visuospatial ability (higher Rey-Osterrieth copy scores vs. health education, <i>p</i> = 0.034).</p> Conclusions <p>Tai Chi provides superior long-term preservation of global cognition and executive/visuospatial function in T2D-MCI older adults, with nearly 50% achieving clinically meaningful cognitive improvement. As a scalable mind-body intervention, it warrants integration into geriatric preventive care to mitigate dementia risk.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Two-year follow-up assessment of a randomized controlled trial evaluating the durability of Tai Chi on cognitive function in older adults with type 2 diabetes and mild cognitive impairment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月6日

查看全文
  • Xia Li,
  • Jia Huang,
  • Haiyin Deng,
  • Zhizhen Liu,
  • Yize Ruan,
  • Zhenming Huang,
  • Yannan Chen,
  • Liyuan Tao,
  • Lidian Chen,
  • Jing Tao

摘要

Aims

Building upon established short-term benefits, this study aimed to assess Tai Chi’s durability for preserving global and domain-specific cognition in older adults (≥ 60 years) with type 2 diabetes and mild cognitive impairment (T2D-MCI), compared to fitness walking and health education.

Methods

Participants (n = 328) were randomized 1:1:1 to Tai Chi, fitness walking, or health education groups, completing 24-week interventions. Cognitive outcomes—global cognition (Montreal Cognitive Assessment, MoCA), executive function, attention, visuospatial ability, and language fluency—were evaluated at baseline, 24 weeks(post-intervention), 36 weeks, and 2 years. Linear mixed models analyzed group-by-time interactions, while time-dependent Cox regression quantified minimal clinically important difference (MCID) attainment (MoCA improvement ≥ 4 points).

Results

At 2-year follow-up, linear mixed models revealed significant group-by-time interactions for MoCA (p < 0.001). The Tai Chi group showed greater MoCA improvement versus health education (mean difference: 1.8, 95% CI 0.3–3.3, p = 0.016). Crucially, 49.8% of Tai Chi practitioners achieved MCID—nearly double the probability of health education (HR 2.0, 95% CI 1.4–2.8, p < 0.001) and exceeding fitness walking (HR 1.7, 95% CI 1.2–2.4; p = 0.005). Tai Chi selectively enhanced executive function (shorter Stroop reaction times vs. health education, p < 0.05; fewer color-word errors vs. fitness walking, p = 0.049) and visuospatial ability (higher Rey-Osterrieth copy scores vs. health education, p = 0.034).

Conclusions

Tai Chi provides superior long-term preservation of global cognition and executive/visuospatial function in T2D-MCI older adults, with nearly 50% achieving clinically meaningful cognitive improvement. As a scalable mind-body intervention, it warrants integration into geriatric preventive care to mitigate dementia risk.