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Objectives <p>Dynapenic abdominal obesity (DAO) may potentially increase risk for mild cognitive impairment (MCI), but data is scarce, and community-based studies are lacking. Thus, we aimed to investigate the association between DAO and MCI in a large nationally representative community-based sample from six LMICs (China, Ghana, India, Mexico, Russia, South Africa).</p> Methods <p>We analyzed cross-sectional data from the Study on Global Ageing and Adult Health. Dynapenia was defined as handgrip strength of &lt; 26&#xa0;kg for men and &lt; 16&#xa0;kg for women. Abdominal obesity was defined as waist circumference of &gt; 88&#xa0;cm for women and &gt; 102&#xa0;cm for men. DAO was defined as having both dynapenia and abdominal obesity. The National Institute on Ageing-Alzheimer’s Association criteria were used to define MCI. Multivariable logistic regression was performed.</p> Results <p>Data on 32,715 individuals aged ≥ 50 years were analyzed [mean (SD) age 62.1 (15.6) years; 48.3% males]. Among those aged 50–64 years, dynapenia alone and DAO were significantly associated with MCI with the OR for DAO (OR = 1.79; 95%CI = 1.26–2.56) being higher than that of dynapenia alone (OR = 1.40; 95%CI = 1.15–1.71). In those aged ≥ 65 years, only dynapenia alone (OR = 1.53; 95%CI = 1.23–1.89) was significantly associated with MCI but not DAO. Abdominal obesity alone was not significantly associated with MCI in both age groups.</p> Conclusions <p>Among community-dwellers in six LMICs, DAO was significantly associated with MCI among middle-aged individuals, but not among older people. However, it is important to note that the study was cross-sectional in nature, and thus, it is not known whether DAO leads to MCI or vice versa. Therefore, future longitudinal studies are necessary to clarify temporal associations and possible causality.</p>

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Association between dynapenic abdominal obesity and mild cognitive impairment among middle-aged and older community-dwelling adults

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月28日

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  • Lee Smith,
  • Guillermo F. López Sánchez,
  • Pinar Soysal,
  • Nicola Veronese,
  • Masoud Rahmati,
  • Karel Kostev,
  • Louis Jacob,
  • Mark A. Tully,
  • Fiona Richardson,
  • Laurie Butler,
  • Yvonne Barnett,
  • Helen Keyes,
  • Jae Il Shin,
  • Ai Koyanagi

摘要

Objectives

Dynapenic abdominal obesity (DAO) may potentially increase risk for mild cognitive impairment (MCI), but data is scarce, and community-based studies are lacking. Thus, we aimed to investigate the association between DAO and MCI in a large nationally representative community-based sample from six LMICs (China, Ghana, India, Mexico, Russia, South Africa).

Methods

We analyzed cross-sectional data from the Study on Global Ageing and Adult Health. Dynapenia was defined as handgrip strength of < 26 kg for men and < 16 kg for women. Abdominal obesity was defined as waist circumference of > 88 cm for women and > 102 cm for men. DAO was defined as having both dynapenia and abdominal obesity. The National Institute on Ageing-Alzheimer’s Association criteria were used to define MCI. Multivariable logistic regression was performed.

Results

Data on 32,715 individuals aged ≥ 50 years were analyzed [mean (SD) age 62.1 (15.6) years; 48.3% males]. Among those aged 50–64 years, dynapenia alone and DAO were significantly associated with MCI with the OR for DAO (OR = 1.79; 95%CI = 1.26–2.56) being higher than that of dynapenia alone (OR = 1.40; 95%CI = 1.15–1.71). In those aged ≥ 65 years, only dynapenia alone (OR = 1.53; 95%CI = 1.23–1.89) was significantly associated with MCI but not DAO. Abdominal obesity alone was not significantly associated with MCI in both age groups.

Conclusions

Among community-dwellers in six LMICs, DAO was significantly associated with MCI among middle-aged individuals, but not among older people. However, it is important to note that the study was cross-sectional in nature, and thus, it is not known whether DAO leads to MCI or vice versa. Therefore, future longitudinal studies are necessary to clarify temporal associations and possible causality.