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Objective <p>Despite several studies assessing the impact of resveratrol on obesity indices, previous meta-analyses show conflicting results. Therefore, we conducted this critical umbrella review of interventional meta-analyses on the effect of resveratrol supplementation on body mass index (BMI), body weight (BW), waist circumference (WC), and body fat.</p> Methods <p>Searches were conducted across multiple databases to identify all relevant meta-analyses up to September 30th, 2025. Reported pooled effect sizes (ESs) and 95% confidence intervals (CIs) were extracted from each included study and synthesized using a random-effects model. Methodological quality was assessed using the AMSTAR 2 tool.</p> Results <p>Ultimately, 18 meta-analyses were included, with results showing a small but statistically significant reduction in BW (ES: − 0.18 kg, 95% CI − 0.32 to − 0.03, <i>p</i> = 0.02), BMI (ES: − 0.14 kg/m<sup>2</sup>, 95% CI − 0.2 to − 0.08, <i>p</i> &lt; 0.001), WC (ES − 0.43 cm, 95% CI − 0.64 to − 0.22, <i>p</i> &lt; 0.001), and body fat (ES: − 0.3 kg, 95% CI − 0.48 to − 0.12, <i>p</i> = 0.001) in the resveratrol group compared to the control group, with subgroup analysis revealing statistical significance only in subgroups with doses &gt; 400 mg/day and study duration ˃ 12 weeks.</p> Conclusion <p>Our review confirms that resveratrol supplementation reduces BW, BMI, WC, and body fat, particularly on doses &gt; 400 mg/day and interventions lasting ˃12 weeks, with small effect sizes. Based on our findings, resveratrol supplementation could be considered as a complementary therapy in the management of obesity.</p>

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The effect of resveratrol supplementation on obesity indices: a critical umbrella review of interventional meta-analyses

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月29日

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  • Ahmed Abu-Zaid,
  • Saleh A. K. Saleh,
  • Heba M. Adly,
  • Abdul Rahman Adi,
  • Emad Kutbi,
  • Nawal Alshammari,
  • Suha Jafar Albahrani,
  • Mona Ahmed Al Shaikh,
  • Marwah Ali Mohammed Al-Agsam,
  • Abdullah M. Alharran

摘要

Objective

Despite several studies assessing the impact of resveratrol on obesity indices, previous meta-analyses show conflicting results. Therefore, we conducted this critical umbrella review of interventional meta-analyses on the effect of resveratrol supplementation on body mass index (BMI), body weight (BW), waist circumference (WC), and body fat.

Methods

Searches were conducted across multiple databases to identify all relevant meta-analyses up to September 30th, 2025. Reported pooled effect sizes (ESs) and 95% confidence intervals (CIs) were extracted from each included study and synthesized using a random-effects model. Methodological quality was assessed using the AMSTAR 2 tool.

Results

Ultimately, 18 meta-analyses were included, with results showing a small but statistically significant reduction in BW (ES: − 0.18 kg, 95% CI − 0.32 to − 0.03, p = 0.02), BMI (ES: − 0.14 kg/m2, 95% CI − 0.2 to − 0.08, p < 0.001), WC (ES − 0.43 cm, 95% CI − 0.64 to − 0.22, p < 0.001), and body fat (ES: − 0.3 kg, 95% CI − 0.48 to − 0.12, p = 0.001) in the resveratrol group compared to the control group, with subgroup analysis revealing statistical significance only in subgroups with doses > 400 mg/day and study duration ˃ 12 weeks.

Conclusion

Our review confirms that resveratrol supplementation reduces BW, BMI, WC, and body fat, particularly on doses > 400 mg/day and interventions lasting ˃12 weeks, with small effect sizes. Based on our findings, resveratrol supplementation could be considered as a complementary therapy in the management of obesity.