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<p>A simple method for direct laser writing of microfluidic channels having a rounded cross-section profile in polydimethylsiloxane (PDMS) is presented. By enclosing the substrate between two microscope glass slides, a pulsed ultraviolet laser (355&#xa0;nm) was applied for obtaining channels with cross-sectional profiles resembling the Greek letter Ω and clean edges. Pulse frequencies between 1 and 500&#xa0;kHz, writing speeds between 1 and 50&#xa0;mm/s and 15 µJ or 60 µJ values of pulse energy were adopted for writing, using both open and confined sample configurations. The channels formed in confined conditions exhibited smaller widths and depths when compared to those processed in open air. The channels formed using the higher pulse energy, in air, had an almost triangular profile (wide &gt; 400&#xa0;μm), while the confined sample subjected to the same laser irradiation had a channel width smaller than 150&#xa0;μm, with a rounded profile. Using the confined approach, a flow-focused microfluidic droplet generator was successfully fabricated and tested. The method is fast, simple and inexpensive, yielding high quality channels for PDMS microfluidic devices. By combining channels made in both open and closed configurations, the range of dimensions and cross-sectional profiles can be further extended and adapted for particular applications.</p>

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Direct Laser Patterning of PDMS for Microfluidic Channels with Rounded Cross-Section Profiles

  • 期刊论文

  • 发表日期：

    2025年9月3日

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  • Daniel S. De Lara,
  • Vivian M. Andrade,
  • Fernando C. Rufino,
  • Ricardo C. Teixeira,
  • Raluca Savu,
  • Ednan Joanni

摘要

A simple method for direct laser writing of microfluidic channels having a rounded cross-section profile in polydimethylsiloxane (PDMS) is presented. By enclosing the substrate between two microscope glass slides, a pulsed ultraviolet laser (355 nm) was applied for obtaining channels with cross-sectional profiles resembling the Greek letter Ω and clean edges. Pulse frequencies between 1 and 500 kHz, writing speeds between 1 and 50 mm/s and 15 µJ or 60 µJ values of pulse energy were adopted for writing, using both open and confined sample configurations. The channels formed in confined conditions exhibited smaller widths and depths when compared to those processed in open air. The channels formed using the higher pulse energy, in air, had an almost triangular profile (wide > 400 μm), while the confined sample subjected to the same laser irradiation had a channel width smaller than 150 μm, with a rounded profile. Using the confined approach, a flow-focused microfluidic droplet generator was successfully fabricated and tested. The method is fast, simple and inexpensive, yielding high quality channels for PDMS microfluidic devices. By combining channels made in both open and closed configurations, the range of dimensions and cross-sectional profiles can be further extended and adapted for particular applications.