<p>This paper explores the possibilities of using a piled raft foundation scheme subjected to seismic loading in Dhaka soil. A series of three-dimensional dynamic finite element analyses were performed for a forty-story reinforced concrete structure with five basement levels. The models incorporated parametric variations in raft thicknesses (2.5, 3.0, and 3.5 m), pile diameters (1.0, 1.2, and 1.5 m), and pile quantities (58, 69, and 82) under gravity and seismic loading. Increasing pile diameter from 1.0 m to 1.2 m reduced differential settlement by approximately 14%, and from 1.0 m to 1.5 m resulted in a 29% reduction. The raft carried approximately 70–80% of the total vertical load on medium-dense to dense silty sand, due to the soil’s stiffness and low compressibility, while the piles primarily contributed to controlling settlement. The influence of raft thickness on reducing differential settlement decreased when pile numbers and diameters were higher, as the piles contributed more significantly to overall stiffness. Notably, settlement due to gravity loads was found to exceed that caused by seismic forces for this high-rise structure. Optimizing raft thickness and pile geometry significantly improved foundation performance by reducing both total and differential settlements. These findings offer a rational design strategy for high-rise piled raft systems in seismic zones with complex subsurface conditions.</p>