<p>The rhizosphere is a dynamic biochemical interface where plant roots, soil minerals, and microbial communities interact to regulate nutrient acquisition and plant productivity. Recent advances in rhizosphere biochemistry, microbial ecology, and biotechnology highlight the potential of this zone as a strategic target for sustainable nutrient delivery. Root exudates shape microbial consortia that mobilize nitrogen, phosphorus, and micronutrients while reducing fertilizer losses and environmental impacts. Emerging tools—including synthetic microbial consortia, genotype-specific exudation profiles, and multi-omics-driven modeling—offer new opportunities to engineer the rhizosphere for improved nutrient-use efficiency. This commentary synthesizes current knowledge and outlines future directions for leveraging rhizosphere processes to support climate-smart agriculture and sustainable intensification.</p>