<p>Sexual assault is a pervasive problem throughout the world, including the U.S. where estimates appear to be rising. Many individuals who experience sexual trauma go on to develop Post-traumatic Stress Disorder (PTSD), a trauma and stressor-related disorder that impacts nearly 5% of the U.S. population each year. Psychedelics have garnered attention in recent years as a potential alternative to traditional forms of treatment, which include psychotherapies (e.g., exposure-based interventions) or pharmacotherapy, including SSRI medication. Psychedelic-assisted therapy typically involves controlled drug administration in a supportive or therapeutic environment. As we will describe, the potential mechanisms of various psychedelics include improved extinction to trauma-related stimuli and memory consolidation. Psychedelics might also improve the therapeutic alliance by increasing one’s feelings of trust, empathy, and connection. However, these same effects can increase vulnerability to inappropriate sexual contact, including sexual assault. Individuals have come forward to share their experiences of sexual assault and exploitation within clinical trials, at psychedelic retreats, and in their own communities. The purpose of this narrative review is to draw attention to the problem of sexual assault among individuals who consume psychedelics, including those who may seek psychedelic-assisted treatment to improve or resolve their sexual trauma.</p>