Purpose To address three integration gaps in psychedelic therapy: (1) absence of standardized multidimensional assessment tools, (2) protocols that may not fully address ecological, somatic, relational and existential domains, and (3) limited cultural accessibility and scalability. We present the THRIVE Model of Psychedelic Integration - The Outdoors (nature connection), Holistic Health (somatic and lifestyle factors), Relationships (social connections), Internal Self (psychological insight), Values (personal principles), and Existential Meaning (spiritual dimensions) - and its companion THRIVE Respondent Interview Protocol (TRIP). Recent Findings Current psychedelic therapy trials show limited standardization of integration protocols. Yaden et al. found that only 14% of psilocybin trials reported formal integration metrics (Psychedelic Med (New Rochelle). 3(1):1–18, <CitationRef CitationID="CR11">2025</CitationRef>). Brennan et al. observed that 82% of trials have not assessed integration fidelity (Psychedelic Med (New Rochelle). 1(4):218–29, <CitationRef CitationID="CR124">2023</CitationRef>). Existing protocols primarily adapt Western psychotherapeutic approaches, with limited incorporation of traditional integration practices. No integration-specific measurement tools have established discriminant validity, predictive validity for long-term outcomes, or measurement invariance across different psychedelic compounds. Summary The THRIVE Model proposes six interconnected facets for integration support. This framework attempts to synthesize evidence-based clinical practices with traditional knowledge systems through a flexible structure allowing cultural adaptation. TRIP operationalizes assessment across all facets through a semi-structured 60–120-minute interview that generates individualized integration plans. Preliminary retrospective data suggest multidimensional approaches may enhance outcomes, with nature-based practices, values work, and extended peer support showing associations with self-reported transformation maintenance at one-year follow-up. However, these findings derive from retrospective analyses with significant limitations including potential recall bias, lack of control groups, self-selected underground therapy participants, and reliance on self-report measures. Randomized controlled trials comparing THRIVE-based integration to current standards are needed to establish effectiveness. The model addresses implementation through tiered training approaches and multiple delivery modalities while maintaining assessment standardization.

The THRIVE Model of Psychedelic Integration: A Holistic Framework Bridging Indigenous Knowledge and Evidence-Based Practice

期刊论文
发表日期：

2025年10月20日

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Ashvind N. Adkins Singh,
Glauber Loures de Assis

摘要

Purpose

To address three integration gaps in psychedelic therapy: (1) absence of standardized multidimensional assessment tools, (2) protocols that may not fully address ecological, somatic, relational and existential domains, and (3) limited cultural accessibility and scalability. We present the THRIVE Model of Psychedelic Integration - The Outdoors (nature connection), Holistic Health (somatic and lifestyle factors), Relationships (social connections), Internal Self (psychological insight), Values (personal principles), and Existential Meaning (spiritual dimensions) - and its companion THRIVE Respondent Interview Protocol (TRIP).

Recent Findings

Current psychedelic therapy trials show limited standardization of integration protocols. Yaden et al. found that only 14% of psilocybin trials reported formal integration metrics (Psychedelic Med (New Rochelle). 3(1):1–18, 2025). Brennan et al. observed that 82% of trials have not assessed integration fidelity (Psychedelic Med (New Rochelle). 1(4):218–29, 2023). Existing protocols primarily adapt Western psychotherapeutic approaches, with limited incorporation of traditional integration practices. No integration-specific measurement tools have established discriminant validity, predictive validity for long-term outcomes, or measurement invariance across different psychedelic compounds.

Summary

The THRIVE Model proposes six interconnected facets for integration support. This framework attempts to synthesize evidence-based clinical practices with traditional knowledge systems through a flexible structure allowing cultural adaptation. TRIP operationalizes assessment across all facets through a semi-structured 60–120-minute interview that generates individualized integration plans. Preliminary retrospective data suggest multidimensional approaches may enhance outcomes, with nature-based practices, values work, and extended peer support showing associations with self-reported transformation maintenance at one-year follow-up. However, these findings derive from retrospective analyses with significant limitations including potential recall bias, lack of control groups, self-selected underground therapy participants, and reliance on self-report measures. Randomized controlled trials comparing THRIVE-based integration to current standards are needed to establish effectiveness. The model addresses implementation through tiered training approaches and multiple delivery modalities while maintaining assessment standardization.