Purpose of Review <p>Maintaining effective plaque control during fixed orthodontic treatment can be challenging because brackets and archwires create areas where plaque easily accumulates. Orthodontic-specific toothbrushes are commonly recommended to help clean around these appliances, but their effectiveness often depends on the user’s brushing technique and consistency. Mechanically powered toothbrushes may assist plaque removal through automated oscillating and rotating movements that reduce reliance on manual skill. This systematic review and meta-analysis aimed to compare the effectiveness of mechanically powered toothbrushes with orthodontic-specific toothbrushes in reducing dental plaque among individuals undergoing fixed orthodontic treatment.</p> Recent Findings <p>A comprehensive search of eight electronic databases and additional sources was conducted to identify randomized controlled trials comparing mechanically powered toothbrushes with orthodontic-specific toothbrushes. Risk of bias was assessed using the Cochrane RoB 2 tool, and the certainty of evidence was evaluated using the GRADE approach. Of the 10,790 records identified, five studies met the inclusion criteria for qualitative synthesis, and three were eligible for meta-analysis. The pooled results showed a statistically significant difference between the two groups favouring the orthodontic-specific toothbrushes (SMD: 0.93; 95% CI: 0.09 to 1.78; <i>p</i> = 0.03); however, this result should be interpreted with caution given the considerable variability between the studies (I² = 92%; <i>p</i> &lt; 0.00001).</p> Summary <p>Orthodontic-specific toothbrushes appeared to reduce plaque more effectively, but this finding should be viewed with caution due to high variability between studies and low certainty of evidence. In everyday practice, plaque control is influenced far more by proper brushing technique, regular oral hygiene habits, and personalized guidance than by the type of toothbrush used.</p>