Purpose of Review <p>This scoping review aims to explore recent research on the use of antimicrobial peptides (AMPs) in dental materials.</p> Recent Findings <p>AMPs are gaining attention as a viable alternative to antibiotics to combat antibiotic resistance. Significant progress has been made in developing bioactive materials containing AMPs due to advancements in synthetic AMP design.</p> Summary <p>The primary applications AMPs in dental materials include enhancing dental implants to improve antibiofilm activity and promote osseointegration, as well as integrating them into dental adhesives. Most research conducted has been in vitro, primarily focusing on synthetic AMPs. While clinical applications have not yet been realized, there is a noticeable trend toward the development of biomaterials that exhibit anti-biofilm and bio-modulatory properties. Future research should emphasize testing these biomaterials under conditions simulating the oral cavity environment, considering the complex microbiological, chemical, and mechanical challenges over extended evaluation periods in the oral environment.</p>

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The Use of Antimicrobial Peptides in Dental Materials: State of the Art

  • Ana Carolina C. Pereira,
  • Thalya Fernanda H. Maltarollo,
  • Mary Caroline Skelton-Macedo,
  • Mutlu Özcan,
  • Ericka T. Pinheiro

摘要

Purpose of Review

This scoping review aims to explore recent research on the use of antimicrobial peptides (AMPs) in dental materials.

Recent Findings

AMPs are gaining attention as a viable alternative to antibiotics to combat antibiotic resistance. Significant progress has been made in developing bioactive materials containing AMPs due to advancements in synthetic AMP design.

Summary

The primary applications AMPs in dental materials include enhancing dental implants to improve antibiofilm activity and promote osseointegration, as well as integrating them into dental adhesives. Most research conducted has been in vitro, primarily focusing on synthetic AMPs. While clinical applications have not yet been realized, there is a noticeable trend toward the development of biomaterials that exhibit anti-biofilm and bio-modulatory properties. Future research should emphasize testing these biomaterials under conditions simulating the oral cavity environment, considering the complex microbiological, chemical, and mechanical challenges over extended evaluation periods in the oral environment.