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Objective of Review <p>Cancer is a massive health problem worldwide that has many molecular complexities and drug-resistant issues. Phytochemicals have gained attention for their anticancer effects, which can act on multiple targets. The aim of review is to investigate the phytochemical composition and anticancer mechanism of <i>Drynaria quercifolia</i>.</p> Current Research <p>Findings in recent years have established that <i>Drynaria quercifolia</i> contains various kinds of phytochemicals (such as flavonoids/phenolic acids/terpenoids), which inhibit the proliferation of cancer cells (SAOS2/A549). These compounds also induce apoptosis and oxidative stress and interfere with key signalling pathways (NF-κB/PI3K/AKT). In addition, some recent studies have shown the results of autophagy and ferroptosis.</p> Summary <p><i>Drynaria quercifolia</i> has potential bioactive compounds that can be utilized for anticancer purposes. However, further in vivo and clinical studies will be required to prove its therapeutic usefulness and to demonstrate its translatability. </p>

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Elucidating the Phytochemical Diversity and Anticancer Mechanisms of Drynaria quercifolia

  • 期刊论文

  • 发表日期：

    2026年8月3日

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  • Vadivelu Deepika,
  • M. Muthukumaran,
  • Boopathy Usharani

摘要

Objective of Review

Cancer is a massive health problem worldwide that has many molecular complexities and drug-resistant issues. Phytochemicals have gained attention for their anticancer effects, which can act on multiple targets. The aim of review is to investigate the phytochemical composition and anticancer mechanism of Drynaria quercifolia.

Current Research

Findings in recent years have established that Drynaria quercifolia contains various kinds of phytochemicals (such as flavonoids/phenolic acids/terpenoids), which inhibit the proliferation of cancer cells (SAOS2/A549). These compounds also induce apoptosis and oxidative stress and interfere with key signalling pathways (NF-κB/PI3K/AKT). In addition, some recent studies have shown the results of autophagy and ferroptosis.

Summary

Drynaria quercifolia has potential bioactive compounds that can be utilized for anticancer purposes. However, further in vivo and clinical studies will be required to prove its therapeutic usefulness and to demonstrate its translatability.