<p>Tart cherry (TC; <i>Prunus cerasus</i>) has high antioxidant and anti-inflammatory potentials due to its rich bioactive components like anthocyanins, polyphenols, vitamins, beta-carotene, ellagic acid, and chlorogenic acid. Oxidative damage and inflammation are underlying reasons to chronic disease pathogenesis. Oxidative stress usually caused by the imbalance between antioxidants and pro-oxidants. Additionally, a chronic inflammatory state is typically modulated by oxidative stress. Inflammation plays a critical role in chronic health conditions, such as cardiovascular diseases, hypertension, insulin resistance, arthritis and cancer. Numerous studies indicate that there is a strong relationship between TC and the inhibition of inflammation and oxidative damage by regulating different epigenetic and metabolic pathways. In this review, the recent developments of TC components and their metabolites on inflammatory and oxidative damages will be discussed, and the challenges and limitations to better support future research, including clinical trials to confirm these findings.</p> Graphical Abstract <p></p>