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Purpose of Review <p> <!--Query ID="Q1" Text="Please confirm if the section headings are correctly identified." Resolved="yes"-->This review evaluates the advancements in high throughput sequencing and AI driven analytics in metagenomic bioprospecting, which has revolutionized the food and pharmaceutical industries by unlocking the potential of microorganisms for various applications. It emphasizes the role of metagenomics in identifying novel bioactive compounds, enabling microbial potentials, and developing sustainable bioprocesses.</p> Recent Findings <p>New sequencing technologies like Oxford Nanopore and PacBio, combined with AI driven computational tools, have significantly improved metagenomic applications in various sectors. In the food industry, metagenomic screening helps identify new food enzymes, optimizes fermentation processes, and improves food safety. In the pharmaceutical sector, metagenomics accelerates antibiotic discovery, facilitates microbiome based therapeutic methods, and enables personalized medication and immunization. Combining synthetic biology with metagenomic bioprospecting enhances microbial potential, enabling bioengineering, biosensor development, and nutrient recovery from waste.</p> Summary <p>Despite countable limitations such as data complexity, high sequencing costs, and lack of standardised protocols, the ongoing development of third generation sequencing and AI/ML analytics promises a near future of enhanced accuracy, accessibility, and affordability. In light of these prospective advancements, metagenomic bioprospecting is set to become a pivotal crutch of future biotechnological innovations.</p>

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Advances in Microbial Metagenomics for Bioprospecting in Nutraceuticals and Pharmaceuticals

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • Angelin Priscilla,
  • Arunmozhi Bharathi Achudhan,
  • Lilly. M. Saleena

摘要

Purpose of Review

This review evaluates the advancements in high throughput sequencing and AI driven analytics in metagenomic bioprospecting, which has revolutionized the food and pharmaceutical industries by unlocking the potential of microorganisms for various applications. It emphasizes the role of metagenomics in identifying novel bioactive compounds, enabling microbial potentials, and developing sustainable bioprocesses.

Recent Findings

New sequencing technologies like Oxford Nanopore and PacBio, combined with AI driven computational tools, have significantly improved metagenomic applications in various sectors. In the food industry, metagenomic screening helps identify new food enzymes, optimizes fermentation processes, and improves food safety. In the pharmaceutical sector, metagenomics accelerates antibiotic discovery, facilitates microbiome based therapeutic methods, and enables personalized medication and immunization. Combining synthetic biology with metagenomic bioprospecting enhances microbial potential, enabling bioengineering, biosensor development, and nutrient recovery from waste.

Summary

Despite countable limitations such as data complexity, high sequencing costs, and lack of standardised protocols, the ongoing development of third generation sequencing and AI/ML analytics promises a near future of enhanced accuracy, accessibility, and affordability. In light of these prospective advancements, metagenomic bioprospecting is set to become a pivotal crutch of future biotechnological innovations.