Scholarlink

Purposeof Review <p>This review provides an extensive examination of the role, synthesis, and regulation of bile acids (BAs) by a variety of distinct nuclear receptors (NRs), such as the farnesoid X receptor (FXR), liver X receptor (LXR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor (PPAR), vitamin D receptor (VDR), and glucocorticoid receptor (GR). This review also discusses recent advances in the understanding of the molecular mechanisms of NRs, their interactions with bile acids, and their possible therapeutic implications.</p> Recent Findings <p>Cholestatic liver disease develops when impaired bile flow affects the biliary tree. The first and most crucial enzyme involved in bile acid synthesis is cholesterol 7 alpha-hydroxylase (CYP7A1). Farnesoid X receptor (FXR) plays a major role in bile acid homeostasis.</p> Summary <p>NRs such as FXR, LXR, PXR, PPAR, VDR, and GR are key regulators of BA homeostasis. FXRs control the expression of genes involved in BA transport, reabsorption, conjugation, and detoxification. PXR and FXRs protect against BA toxicity by inducing the expression of detoxification enzymes and transporters. The VDR regulates BA and bone metabolism, whereas LXRs regulate cholesterol and BA homeostasis. PPARs control inflammation and detoxification in cholestatic liver injury. GR activates BA transporters in the ileum and liver.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of Nuclear Receptors on the Control of Bile Acid Metabolism and Synthesis: A Comprehensive Review

  • 期刊论文

  • 发表日期：

    2025年4月3日

查看全文
  • Thamer Abdulla Mohammed,
  • Munaf H. Zalzala

摘要

Purposeof Review

This review provides an extensive examination of the role, synthesis, and regulation of bile acids (BAs) by a variety of distinct nuclear receptors (NRs), such as the farnesoid X receptor (FXR), liver X receptor (LXR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor (PPAR), vitamin D receptor (VDR), and glucocorticoid receptor (GR). This review also discusses recent advances in the understanding of the molecular mechanisms of NRs, their interactions with bile acids, and their possible therapeutic implications.

Recent Findings

Cholestatic liver disease develops when impaired bile flow affects the biliary tree. The first and most crucial enzyme involved in bile acid synthesis is cholesterol 7 alpha-hydroxylase (CYP7A1). Farnesoid X receptor (FXR) plays a major role in bile acid homeostasis.

Summary

NRs such as FXR, LXR, PXR, PPAR, VDR, and GR are key regulators of BA homeostasis. FXRs control the expression of genes involved in BA transport, reabsorption, conjugation, and detoxification. PXR and FXRs protect against BA toxicity by inducing the expression of detoxification enzymes and transporters. The VDR regulates BA and bone metabolism, whereas LXRs regulate cholesterol and BA homeostasis. PPARs control inflammation and detoxification in cholestatic liver injury. GR activates BA transporters in the ileum and liver.