The Role of Selenium in Cancer

期刊论文
发表日期：

2024年12月2日

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Ruth Joy Moses,
Great Iruoghene Edo,
Nawar. F. Razooqi,
Tubi Abiola O.,
Tayser Sumer Gaaz,
Alice Njolke Mafe,
Agatha Ngukuran Jikah,
Endurance Fegor Isoje,
Ufuoma Augustina Igbuku,
Patrick Othuke Akpoghelie,
Arthur Efeoghene Athan Essaghah,
Dina S. Ahmed,
Huzaifa Umar

摘要

Purpose of Review

This review summarizes the sources, metabolism and roles of selenium within the human body. Past and recent evidence implicating selenium deficiency as a feature in various cases of cancers is reviewed.

Recent Findings

Trace elements (micronutrients) are nutrients required in minute concentrations in human physiology. Their significance in maintaining homeostatic physiologic states cannot be overlooked. Selenium is an essential micronutrient that is primarily obtained from diet. After being taken up in the duodenum, the micronutrient is disseminated to various target organs where it executes vital roles such as aiding cell apoptosis, promoting anti-oxidation and boosting immunity and cognitive function. The possible link between selenium deficiency and a wide range of diseases especially cancer, has been recognized.

Summary

In recent years, numerous reviews and meta-analyses of research examining the correlation between low levels of Selenium (toenail, serum, and urine) and specific cancer incidences have been published. Finally, suggestions on subsequent directions to further elucidate the function of selenium deficiency in cancer occurrence and prognosis were stated.