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<p>Chimeric antigen receptor (CAR)-T cell therapy is emerging as a promising immunotherapeutic modality for improving clinical outcomes in high-grade gliomas. Three recent studies have demonstrated the safety and feasibility of intracranial CAR-T cell administration in patients with glioblastoma (GBM), along with preliminary evidence of rapid but transient objective responses. These findings provide a rationale for further clinical investigation of this approach.</p>

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Advances in the Optimization of CAR-T-Cell-Based Therapeutic Approaches to Enhance Antitumor Efficacy in Glioblastoma Treatment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月21日

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  • Lidia Gatto,
  • Vincenzo Di Nunno,
  • Alicia Tosoni,
  • Marta Aprile,
  • Chiara Maria Argento,
  • Marzia Margotti,
  • Stefania Bartolini,
  • Enrico Franceschi

摘要

Chimeric antigen receptor (CAR)-T cell therapy is emerging as a promising immunotherapeutic modality for improving clinical outcomes in high-grade gliomas. Three recent studies have demonstrated the safety and feasibility of intracranial CAR-T cell administration in patients with glioblastoma (GBM), along with preliminary evidence of rapid but transient objective responses. These findings provide a rationale for further clinical investigation of this approach.