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Purpose <p>To determine the natural history of the cardiac manifestations, determined by advanced transthoracic echocardiography (TTE), due to COVID-19 in multiethnic hospitalised patients.</p> Methods <p>A prospective observational study, in a London NHS Trust, of patients admitted with COVID-19 undergoing TTE. Baseline TTE was taken during acute admission with follow-up TTE at a median of 17.6&#xa0;months to assess the same left ventricular (LV), right ventricular (RV) and pulmonary pressure parameters with additional 3D and strain measures.</p> Results <p>There were a total of 117 patients with admission and follow-up TTE. LV parameters were largely unchanged at follow-up except E/A ratio decreasing from 0.98 to 0.85. LV global longitudinal strain measures detected subclinical LV impairment in 36% of patients. RV dimensions improved (mean mid RV diameter, 3.1&#xa0;cm to 2.7&#xa0;cm (<i>p</i> &lt; 0.001)) but with persistence of RV impairment at follow-up (28%). 3D RV ejection fraction and global strain measures determined impairment in around 40% of patients. All pulmonary haemodynamic measures showed improvement with resolution of effects of RV afterload (<i>p</i> = 0.016), decrease in pulmonary artery systolic pressure (36&#xa0;mmHg to 28&#xa0;mmHg <i>p</i> = 0.032) and improvements in mean pulmonary valve acceleration time (113&#xa0;ms to 120&#xa0;ms), <i>p</i> = 0.025, and pulmonary vascular resistance (2.2 to 1.7 WU), <i>p</i> = 0.01.</p> Conclusion <p>Follow-up echocardiographic parameters compared to admission parameters of multiethnic hospitalised patients with COVID-19 demonstrate improved pulmonary haemodynamics but persistent LV and RV impairment which suggest possible myocarditic/microthrombotic lasting effects of COVID-19 infection.</p>

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Follow-up study of the cardiac manifestations of multiethnic patients hospitalised with COVID-19

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月30日

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  • Gabriel Bioh,
  • Ashish Patel,
  • Reinette Hampson,
  • Emma Howard,
  • Roxy Senior

摘要

Purpose

To determine the natural history of the cardiac manifestations, determined by advanced transthoracic echocardiography (TTE), due to COVID-19 in multiethnic hospitalised patients.

Methods

A prospective observational study, in a London NHS Trust, of patients admitted with COVID-19 undergoing TTE. Baseline TTE was taken during acute admission with follow-up TTE at a median of 17.6 months to assess the same left ventricular (LV), right ventricular (RV) and pulmonary pressure parameters with additional 3D and strain measures.

Results

There were a total of 117 patients with admission and follow-up TTE. LV parameters were largely unchanged at follow-up except E/A ratio decreasing from 0.98 to 0.85. LV global longitudinal strain measures detected subclinical LV impairment in 36% of patients. RV dimensions improved (mean mid RV diameter, 3.1 cm to 2.7 cm (p < 0.001)) but with persistence of RV impairment at follow-up (28%). 3D RV ejection fraction and global strain measures determined impairment in around 40% of patients. All pulmonary haemodynamic measures showed improvement with resolution of effects of RV afterload (p = 0.016), decrease in pulmonary artery systolic pressure (36 mmHg to 28 mmHg p = 0.032) and improvements in mean pulmonary valve acceleration time (113 ms to 120 ms), p = 0.025, and pulmonary vascular resistance (2.2 to 1.7 WU), p = 0.01.

Conclusion

Follow-up echocardiographic parameters compared to admission parameters of multiethnic hospitalised patients with COVID-19 demonstrate improved pulmonary haemodynamics but persistent LV and RV impairment which suggest possible myocarditic/microthrombotic lasting effects of COVID-19 infection.