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Background <p>Lung ultrasound could be useful tool in prediction and management of bronchopulmonary dysplasia (BPD).</p> Aim <p>This study aimed to assess the effectiveness of the extended lung ultrasound (eLUS) score and posterior zone assessment in predicting BPD.</p> Setting and design <p>Prospective cohort study held at the Neonatal-Intensive-Care Unit of Alexandria-University-Maternity-Hospital between November-2024 and May-2025.</p> Methods <p>A total of 100 neonates with gestational age &lt; 32&#xa0;weeks, still requiring respiratory support on day-7, had regular LUS on days 7, 14, and 28 postnatally. They were categorized into two groups: BPD and non-BPD. A comparative analysis was performed between the groups. The predictive power of LUS for BPD development at 36&#xa0;weeks of postmenstrual age was evaluated by ROC curve analysis.</p> Results <p>The mean (SD) gestational age for the entire group was 29.52 ± 1.05&#xa0;weeks. Infants who developed BPD exhibited statistically higher eLUS scores on both day-7 and day-14 afterbirth (<i>P</i> &lt; 0.001). A day-7 eLUS and posterior zones score cutoff of more than 13 and more than 4 points, respectively, predicted BPD with a sensitivity of 97% and 97.1% and a specificity of 92% and 89.39%. The eLUS score on day-7 exhibited a strong correlation with invasive mechanical ventilation (IMV) on day-7, the duration of IMV, and oxygen saturation index.</p> Conclusions <p>Both eLUS score and posterior zones at day-7 strongly predicts BPD in preterm-infants. Evaluating posterior lung zones appears crucial for improving LUS diagnostic accuracy. LUS scores increased with increasing BPD severity.</p>

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Application of lung ultrasound focusing on posterior zones in prediction of bronchopulmonary dysplasia in preterm infants: a prospective cohort study

  • 期刊论文

  • 发表日期：

    2026年5月1日

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  • Marwa Mohamed Farag,
  • Hesham Abd El-Rahim Ghazal,
  • Mohamed Hazem Wagih Gouda,
  • Ahmed Abd El Halim Khedr

摘要

Background

Lung ultrasound could be useful tool in prediction and management of bronchopulmonary dysplasia (BPD).

Aim

This study aimed to assess the effectiveness of the extended lung ultrasound (eLUS) score and posterior zone assessment in predicting BPD.

Setting and design

Prospective cohort study held at the Neonatal-Intensive-Care Unit of Alexandria-University-Maternity-Hospital between November-2024 and May-2025.

Methods

A total of 100 neonates with gestational age < 32 weeks, still requiring respiratory support on day-7, had regular LUS on days 7, 14, and 28 postnatally. They were categorized into two groups: BPD and non-BPD. A comparative analysis was performed between the groups. The predictive power of LUS for BPD development at 36 weeks of postmenstrual age was evaluated by ROC curve analysis.

Results

The mean (SD) gestational age for the entire group was 29.52 ± 1.05 weeks. Infants who developed BPD exhibited statistically higher eLUS scores on both day-7 and day-14 afterbirth (P < 0.001). A day-7 eLUS and posterior zones score cutoff of more than 13 and more than 4 points, respectively, predicted BPD with a sensitivity of 97% and 97.1% and a specificity of 92% and 89.39%. The eLUS score on day-7 exhibited a strong correlation with invasive mechanical ventilation (IMV) on day-7, the duration of IMV, and oxygen saturation index.

Conclusions

Both eLUS score and posterior zones at day-7 strongly predicts BPD in preterm-infants. Evaluating posterior lung zones appears crucial for improving LUS diagnostic accuracy. LUS scores increased with increasing BPD severity.