Purpose of Review <p><i>Aedes aegypti</i>, the primary vector of dengue virus in Argentina, has a long and complex history marked by eradication campaigns, re-emergence, and continuous expansion into temperate regions. This review aims to synthesize the evolution of chemical control strategies applied in the country, emphasizing both historical context and current approaches to adult and larval mosquito management.</p> Recent Findings <p>The analysis highlights the extensive use of adulticides and larvicides, the growing problem of insecticide resistance, and the key role of national research institutions such as CIPEIN in evaluating and optimizing vector control products. The spread of pyrethroid resistance, driven by knockdown resistance (<i>kdr</i>) mutations (V1016L, F1534C, V410L), has revealed the constraints of existing chemical tools and the urgent need for resistance management through the rotation of alternative insecticide classes such as organophosphates. Additionally, operational challenges—including the decentralization of health services, limited community involvement, and weak intersectoral coordination—further undermine control efforts.</p> Summary <p>Sustainable <i>Ae. aegypti</i> control in Argentina will depend on integrating behavioral insights, community-based participation, and adaptive chemical strategies guided by ongoing resistance surveillance. Strengthening interinstitutional collaboration and developing innovative, evidence-based tools will be essential to enhance long-term vector management and dengue prevention.</p>