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Purpose of Review <p>Global efforts to control soil-transmitted helminths including <i>Trichuris trichiura</i> rely on the administration of benzimidazole drugs, which, after decades of use are increasingly demonstrating reduced efficacy. This rapid review aims to analyze the literature regarding the efficacy and safety of ivermectin (IVM) in combination with benzimidazole (BZ) drugs for <i>T. trichiura</i> infections.</p> Recent Findings <p>Ten randomized controlled trials (RCTs) published in English or Spanish between January 1980 and June 2022 were included in the review. The inclusion criteria included a randomized controlled trial assessing efficacy or safety for ivermectin therapy alone or in combination, as treatment against <i>T. trichiura</i>. All ten studies investigated the efficacy of ivermectin-containing treatments, and only five reported data on safety. In terms of efficacy, a higher cure rate with the combination of IVM + BZ compared to the standard of care drug (400&#xa0;mg albendazole alone) was found in all the analyzed studies that investigated this combination. In term of safety, all the studies reported mild adverse events.</p> Summary <p>In general, the co-administration of IVM + BZ demonstrated excellent efficacy and safety for treating trichuriasis. The findings support the use of combination treatment as an alternative to standard BZ treatment in endemic areas, in particular where <i>T. trichiura</i> remains prevalent. This study contributes to the growing body of evidence supporting the favorable profile of combination of IVM + ALB in <i>Trichuris trichiura</i> control.</p>

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Rapid Review of Evidence: Efficacy and Safety of Ivermectin and Ivermectin-Benzimidazole Administration for the Treatment of Trichuris trichiura in Children

  • 期刊论文

  • 发表日期：

    2025年4月14日

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  • Gabriela Matamoros,
  • Ruben Cimino,
  • Alejandro Krolewiecki,
  • Ana Sanchez

摘要

Purpose of Review

Global efforts to control soil-transmitted helminths including Trichuris trichiura rely on the administration of benzimidazole drugs, which, after decades of use are increasingly demonstrating reduced efficacy. This rapid review aims to analyze the literature regarding the efficacy and safety of ivermectin (IVM) in combination with benzimidazole (BZ) drugs for T. trichiura infections.

Recent Findings

Ten randomized controlled trials (RCTs) published in English or Spanish between January 1980 and June 2022 were included in the review. The inclusion criteria included a randomized controlled trial assessing efficacy or safety for ivermectin therapy alone or in combination, as treatment against T. trichiura. All ten studies investigated the efficacy of ivermectin-containing treatments, and only five reported data on safety. In terms of efficacy, a higher cure rate with the combination of IVM + BZ compared to the standard of care drug (400 mg albendazole alone) was found in all the analyzed studies that investigated this combination. In term of safety, all the studies reported mild adverse events.

Summary

In general, the co-administration of IVM + BZ demonstrated excellent efficacy and safety for treating trichuriasis. The findings support the use of combination treatment as an alternative to standard BZ treatment in endemic areas, in particular where T. trichiura remains prevalent. This study contributes to the growing body of evidence supporting the favorable profile of combination of IVM + ALB in Trichuris trichiura control.