Purpose of Review <p>Autism was initially recognized by Eugen Bleuler as an indicator of Schizophrenia. Since then, Schizophrenia and Autism spectrum disorder have existed as two different disorders with their own clinical profiles. Despite their individual existence, more than a quarter of those diagnosed with ASD are at higher risk of a schizophrenia diagnosis. There is an even greater likelihood for the reverse with more than half of the SSD population at risk of an ASD diagnosis. The overlapping of the two disorders warrants further investigation to better understand the risks and a chance to enhance the capabilities of early identification in the vulnerable ASD population.</p> Recent Findings <p>The research that was reviewed indicates improved detection capabilities using biomarkers.</p> Summary <p>Autism and Schizophrenia are recognized as two distinct diagnoses. Further understanding of the similarities between the two could better equip clinicians to detect and treat early signs of psychosis. Those treated early have a greater chance of a healthy outcome.</p>