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Purpose of Review <p>γδ T cells are a unique subset of lymphocytes that integrate innate and adaptive immune functions. Their ability to rapidly respond to cellular injury and recognize stress-induced ligands makes them key players in immune surveillance and inflammation. This review explores their involvement in alloimmune responses following solid organ transplantation and their response to immunosuppressive therapies.</p> Recent Findings <p>γδ T cells can promote graft rejection by producing IL-17 and exerting cytotoxic effects. However, specific subsets, such as Vδ1<sup>+</sup> γδ T cells, are linked to immune tolerance, particularly in liver transplantation. Immunosuppressive agents impact γδ T cells differently: calcineurin inhibitors suppress their activity, whereas mTOR inhibitors enhance their antiviral and cytotoxic potential.</p> Summary <p>Despite growing evidence, the role of γδ T cells in transplantation remains unclear. Further research is needed to clarify their function and how they could be targeted to improve graft outcomes.</p>

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Gamma Delta T Cells in Solid Organ Transplantation

  • 期刊论文

  • 发表日期：

    2025年5月3日

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  • Carolina Bigatti,
  • Lorenzo Cocchini,
  • Friederike Selbach,
  • Andrea Angeletti,
  • Paolo Cravedi

摘要

Purpose of Review

γδ T cells are a unique subset of lymphocytes that integrate innate and adaptive immune functions. Their ability to rapidly respond to cellular injury and recognize stress-induced ligands makes them key players in immune surveillance and inflammation. This review explores their involvement in alloimmune responses following solid organ transplantation and their response to immunosuppressive therapies.

Recent Findings

γδ T cells can promote graft rejection by producing IL-17 and exerting cytotoxic effects. However, specific subsets, such as Vδ1+ γδ T cells, are linked to immune tolerance, particularly in liver transplantation. Immunosuppressive agents impact γδ T cells differently: calcineurin inhibitors suppress their activity, whereas mTOR inhibitors enhance their antiviral and cytotoxic potential.

Summary

Despite growing evidence, the role of γδ T cells in transplantation remains unclear. Further research is needed to clarify their function and how they could be targeted to improve graft outcomes.