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Purpose of Review <p>The 55 US organ procurement organizations (OPOs) play a central role in transplantation. OPOs are required to maximize quality and number of organs transplanted; normothermic regional perfusion (NRP) promotes these donation outcomes from donation after circulatory determination of death (DCD) donors.</p> Recent Findings <p>Most reports of NRP benefits have been from transplant centers; there is 1 recent OPO-based NRP publication, showing improved organ utilization in non-thoracic donors. A recent survey of OPOs’ experience showed 606 cases had been coordinated through 2023, predominantly at the request of a transplant center. Barely half of OPOs (53%) had a policy approved or pending approval. Large heterogeneity of practice/experience and the need for guidelines/standards were study highlights. We collectively performed 533 NRP recoveries in 2024. Benefits of OPO-based NRP and ideas for future direction, which requires more process standardization, are outlined.</p> Summary <p>Expansion of OPO-based NRP is necessary to maximize DCD donation outcomes.</p>

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Organ Procurement Organization-Based Normothermic Regional Perfusion in the US: Current State and Future Direction

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月2日

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  • Marty T. Sellers,
  • Charles Strom,
  • Deana C. Clapper,
  • Richard D. Hasz,
  • John M. Edwards

摘要

Purpose of Review

The 55 US organ procurement organizations (OPOs) play a central role in transplantation. OPOs are required to maximize quality and number of organs transplanted; normothermic regional perfusion (NRP) promotes these donation outcomes from donation after circulatory determination of death (DCD) donors.

Recent Findings

Most reports of NRP benefits have been from transplant centers; there is 1 recent OPO-based NRP publication, showing improved organ utilization in non-thoracic donors. A recent survey of OPOs’ experience showed 606 cases had been coordinated through 2023, predominantly at the request of a transplant center. Barely half of OPOs (53%) had a policy approved or pending approval. Large heterogeneity of practice/experience and the need for guidelines/standards were study highlights. We collectively performed 533 NRP recoveries in 2024. Benefits of OPO-based NRP and ideas for future direction, which requires more process standardization, are outlined.

Summary

Expansion of OPO-based NRP is necessary to maximize DCD donation outcomes.