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Purpose of Review <p>Sedentary behavior is increasingly recognized as an independent risk factor for cardiovascular disease (CVD), yet prevention efforts continue to emphasize aerobic exercise while underutilizing resistance training (RT). This review synthesizes recent evidence (2018–2025) examining how sedentary behavior, physical activity, and RT jointly influence cardiovascular risk, with particular attention to translational and population health implications.</p> Recent Findings <p>Large-scale epidemiologic studies consistently link prolonged sedentary time to increased cardiovascular morbidity and mortality, even among physically active adults. Emerging mechanistic and intervention evidence demonstrates that RT favorably modifies vascular function, metabolic health, autonomic regulation, and functional capacity. Community- and clinic-based RT interventions show promise in reducing sedentary risk, particularly among older adults and high-risk populations.</p> Summary <p>Reframing cardiovascular prevention to explicitly include RT offers a scalable, equitable, and physiologically targeted strategy to counteract sedentary behavior–related cardiovascular risk. Greater integration of RT into research, practice, and policy is warranted globally.</p>

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Breaking the Sedentary Cycle: The Role of Resistance Training in Cardiovascular Health and Disease Prevention

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月11日

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  • Marcus A. Johnson

摘要

Purpose of Review

Sedentary behavior is increasingly recognized as an independent risk factor for cardiovascular disease (CVD), yet prevention efforts continue to emphasize aerobic exercise while underutilizing resistance training (RT). This review synthesizes recent evidence (2018–2025) examining how sedentary behavior, physical activity, and RT jointly influence cardiovascular risk, with particular attention to translational and population health implications.

Recent Findings

Large-scale epidemiologic studies consistently link prolonged sedentary time to increased cardiovascular morbidity and mortality, even among physically active adults. Emerging mechanistic and intervention evidence demonstrates that RT favorably modifies vascular function, metabolic health, autonomic regulation, and functional capacity. Community- and clinic-based RT interventions show promise in reducing sedentary risk, particularly among older adults and high-risk populations.

Summary

Reframing cardiovascular prevention to explicitly include RT offers a scalable, equitable, and physiologically targeted strategy to counteract sedentary behavior–related cardiovascular risk. Greater integration of RT into research, practice, and policy is warranted globally.